Sephin-1

Modify Date: 2024-01-08 12:44:52

Sephin-1 Structure
Sephin-1 structure
Common Name Sephin-1
CAS Number 13098-73-2 Molecular Weight 196.63700
Density 1.35g/cm3 Boiling Point 374.2ºC at 760 mmHg
Molecular Formula C8H9ClN4 Melting Point N/A
MSDS N/A Flash Point 180.1ºC

 Use of Sephin-1


(E/Z)-Icerguastat ((E/Z)-Sephin1) is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). (E/Z)-Icerguastat can be used for protein misfolding diseases research[1].

 Names

Name 2-[(E)-(2-chlorophenyl)methylideneamino]guanidine
Synonym More Synonyms

 Sephin-1 Biological Activity

Description (E/Z)-Icerguastat ((E/Z)-Sephin1) is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). (E/Z)-Icerguastat can be used for protein misfolding diseases research[1].
Related Catalog
Target

PPP1R15A[1]

References

[1]. Das I, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015 Apr 10;348(6231):239-42.

 Chemical & Physical Properties

Density 1.35g/cm3
Boiling Point 374.2ºC at 760 mmHg
Molecular Formula C8H9ClN4
Molecular Weight 196.63700
Flash Point 180.1ºC
Exact Mass 196.05200
PSA 74.26000
LogP 2.34790
Vapour Pressure 8.5E-06mmHg at 25°C
Index of Refraction 1.626

 Synonyms

Sephin-1
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