(2Z)-3-[3-[3-甲氧基-5-(三氟甲基)苯基]-1H-1,2,4-三唑-1-基]-2-丙烯酸异丙酯

更新时间：2025-08-31 21:17:06

(2Z)-3-[3-[3-甲氧基-5-(三氟甲基)苯基]-1H-1,2,4-三唑-1-基]-2-丙烯酸异丙酯结构式	常用名	(2Z)-3-[3-[3-甲氧基-5-(三氟甲基)苯基]-1H-1,2,4-三唑-1-基]-2-丙烯酸异丙酯	英文名	KPT-185
	CAS号	1333151-73-7	分子量	355.312
	密度	1.3±0.1 g/cm3	沸点	458.8±55.0 °C at 760 mmHg
	分子式	C₁₆H₁₆F₃N₃O₃	熔点	N/A
	MSDS	N/A	闪点	231.3±31.5 °C

中文名	(2Z)-3-[3-[3-甲氧基-5-(三氟甲基)苯基]-1H-1,2,4-三唑-1-基]-2-丙烯酸异丙酯
英文名	propan-2-yl (Z)-3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoate
英文别名	更多

描述
相关类别	信号通路 >> 跨膜转运 >> CRM1 研究领域 >> 癌症
参考文献	[1]. Ranganathan P, et al. Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia. Blood. 2012 Aug 30;120(9):1765-73. [2]. Zhang K, et al. Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma. Exp Hematol. 2013 Jan;41(1):67-78.e4. [3]. Salas Fragomeni RA, et al. CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF-mutant melanoma. Mol Cancer Ther. 2013 Jul;12(7):1171-9.

描述

相关类别

信号通路 >> 跨膜转运 >> CRM1

研究领域 >> 癌症

参考文献

[1]. Ranganathan P, et al. Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia. Blood. 2012 Aug 30;120(9):1765-73.

[2]. Zhang K, et al. Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma. Exp Hematol. 2013 Jan;41(1):67-78.e4.

[3]. Salas Fragomeni RA, et al. CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF-mutant melanoma. Mol Cancer Ther. 2013 Jul;12(7):1171-9.

密度	1.3±0.1 g/cm3
沸点	458.8±55.0 °C at 760 mmHg
分子式	C₁₆H₁₆F₃N₃O₃
分子量	355.312
闪点	231.3±31.5 °C
精确质量	355.114380
PSA	66.24000
LogP	4.24
InChIKey	NLNGWFLRRRYNIL-UHFFFAOYSA-N
SMILES	COc1cc(-c2ncn(C=CC(=O)OC(C)C)n2)cc(C(F)(F)F)c1
蒸汽压	0.0±1.1 mmHg at 25°C
折射率	1.526
储存条件	-20°C

危害码 (欧洲)	Xi

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：HCMV UL50
External Id：HMS1262

实验名称：MELAS cybrid survival enhancement under low glucose conditions
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：N/A
External Id：HMS1419

实验名称：Stabilization of p53 in human papillomavirus-positive cells
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：Cellular tumor antigen p53
External Id：HMS1485

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Isopropyl (2Z)-3-{3-[3-methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}acrylate

(Z)-isopropyl 3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

S7125

KPT-185