4-硝基苯基 4-(4-甲氧基苯基)哌嗪-1-甲酸酯

• 常用名: 4-硝基苯基 4-(4-甲氧基苯基)哌嗪-1-甲酸酯
• 英文名: WWL154
• CAS号: 1338574-93-8
• 分子量: 357.36
• 密度: 1.3±0.1 g/cm3
• 沸点: 553.6±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₉N₃O₅
• 熔点: N/A
• 闪点: 288.6±30.1 °C

用途

WWL154是JZL184的类似物,维持SH反应性对硝基苯氨基甲酸酯基团,是FAAH-4抑制剂【1】。

4-硝基苯基 4-(4-甲氧基苯基)哌嗪-1-甲酸酯名称

• 中文名: 4-硝基苯基 4-(4-甲氧基苯基)哌嗪-1-甲酸酯
• 英文名: 4-Nitrophenyl 4-(4-methoxyphenyl)-1-piperazinecarboxylate

4-硝基苯基 4-(4-甲氧基苯基)哌嗪-1-甲酸酯生物活性

• 描述: WWL154是JZL184的类似物,维持SH反应性对硝基苯氨基甲酸酯基团,是FAAH-4抑制剂【1】。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 代谢酶/蛋白酶 >> FAAH
  信号通路 >> 神经信号通路 >> FAAH
• 参考文献:

  [1]. Jürg Gertsch, et al. Scaffold and organism hopping with chemical probes. Nat Chem Biol. 2019 May;15(5):428-429.

4-硝基苯基 4-(4-甲氧基苯基)哌嗪-1-甲酸酯物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 553.6±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₉N₃O₅
• 分子量: 357.36
• 闪点: 288.6±30.1 °C
• 精确质量: 357.132477
• LogP: 3.21
• InChIKey: TULVXRNEEQWFGU-UHFFFAOYSA-N
• SMILES: COc1ccc(N2CCN(C(=O)Oc3ccc([N+](=O)[O-])cc3)CC2)cc1
• 外观性状: 固体
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.609
• 储存条件: 2-8°C， 密封

4-硝基苯基 4-(4-甲氧基苯基)哌嗪-1-甲酸酯安全信息

• 危害码 (欧洲): Xn

4-硝基苯基 4-(4-甲氧基苯基)哌嗪-1-甲酸酯靶点实验

查看更多实验

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：HTS for Bacterial rRNA inhibitors Measured in Microorganism-Based System Using Plate ... 来源：Broad Institute 靶标：N/A External Id：7056-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2mCherry

实验名称：qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): prim... 来源：NCGC 靶标：RecName: Full=Rap guanine nucleotide exchange factor 3; AltName: Full=Exchange factor directly activated by cAMP 1; AltName: Full=Exchange protein directly activated by cAMP 1; Short=EPAC 1; AltName: Full=Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; AltName: Full=cAMP-regulated guanine nucleotide exchange factor I; Short=cAMP-GEFI External Id：EPAC1-agonist-p1

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] External Id：PLCB3_INH_QFRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：ADAM10 [Homo sapiens] External Id：ADAM10_INH_QFRET_1536_1X%INH PRUN

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): prim... 来源：NCGC 靶标：RecName: Full=Rap guanine nucleotide exchange factor 4; AltName: Full=Exchange factor directly activated by cAMP 2; AltName: Full=Exchange protein directly activated by cAMP 2; Short=EPAC 2; AltName: Full=cAMP-regulated guanine nucleotide exchange factor II; Short=cAMP-GEFII External Id：EPAC2-agonist-p1

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4-硝基苯基 4-(4-甲氧基苯基)哌嗪-1-甲酸酯英文别名

• 1-Piperazinecarboxylic acid, 4-(4-methoxyphenyl)-, 4-nitrophenyl ester
• 4-Nitrophenyl 4-(4-methoxyphenyl)-1-piperazinecarboxylate