Doxofylline-d4

• 常用名: Doxofylline-d4
• 英文名: Doxofylline-d4
• CAS号: 1346599-13-0
• 分子量: 270.28
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₁H₁₀D₄N₄O₄
• 熔点: N/A
• 闪点: N/A

Doxofylline-d4用途

多索茶碱-d4是氘标记的多索茶碱。多索茶碱是腺苷A1受体的拮抗剂,它也抑制磷酸二酯酶IV[1][2]。

Doxofylline-d4名称

• 英文名: Doxofylline-d4

Doxofylline-d4生物活性

• 描述: 多索茶碱-d4是氘标记的多索茶碱。多索茶碱是腺苷A1受体的拮抗剂,它也抑制磷酸二酯酶IV[1][2]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Shukla D, et al. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2009 Oct;10(14):2343-56.

Doxofylline-d4物理化学性质

• 分子式: C₁₁H₁₀D₄N₄O₄
• 分子量: 270.28

Doxofylline-d4靶点实验

查看更多实验

实验名称：Inhibition of Pseudomonas aeruginosa-induced apoptosis in C57BL/6 mouse at 80 mg/kg, ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5130370

实验名称：AUC (0 to t) in CD1 mouse at 20 mg/kg, iv measured upto 24 hrs by HPLC-MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5130339

实验名称：Clearance in CD1 mouse at 20 mg/kg, iv measured upto 24 hrs by HPLC-MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5130340

实验名称：Half life in CD1 mouse at 80 mg/kg, po measured upto 24 hrs by HPLC-MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5130341

实验名称：Antifibrotic activity against Pseudomonas aeruginosa-induced pulmonary fibrosis C57BL... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5130367

实验名称：Antifibrotic activity against Pseudomonas aeruginosa-induced pulmonary fibrosis C57BL... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5130368

实验名称：Half life in CD1 mouse at 20 mg/kg, iv measured upto 24 hrs by HPLC-MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5130337

实验名称：Antifibrotic activity against Pseudomonas aeruginosa-induced pulmonary fibrosis C57BL... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5130369

实验名称：Antifibrotic activity against BLM-induced lung injury C57BL/6 mouse model assessed as... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5130362

实验名称：Antifibrotic activity against BLM-induced lung injury C57BL/6 mouse model assessed as... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5130363

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