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Ondansetron-d3 hydrochloride

更新时间:2025-08-27 12:48:46

Ondansetron-d3 hydrochloride结构式
Ondansetron-d3 hydrochloride结构式
品牌特惠专场
常用名 Ondansetron-d3 hydrochloride 英文名 Ondansetron-d3 hydrochloride
CAS号 1346605-02-4 分子量 296.39
密度 N/A 沸点 N/A
分子式 C18H17D3ClN3O 熔点 N/A
MSDS N/A 闪点 N/A

 Ondansetron-d3 hydrochloride用途


恩丹西酮-d3(GR 38032-d3)盐酸盐)是氘标记的恩丹西酮盐酸盐。盐酸昂丹司琼(GR 38032盐酸盐)是一种5-羟色胺5-HT3受体拮抗剂,主要用于止吐(治疗恶心和呕吐),通常在化疗后使用[1][2]。

 Ondansetron-d3 hydrochloride名称

英文名 Ondansetron-d3 hydrochloride

 Ondansetron-d3 hydrochloride生物活性

描述 恩丹西酮-d3(GR 38032-d3)盐酸盐)是氘标记的恩丹西酮盐酸盐。盐酸昂丹司琼(GR 38032盐酸盐)是一种5-羟色胺5-HT3受体拮抗剂,主要用于止吐(治疗恶心和呕吐),通常在化疗后使用[1][2]。
相关类别
体外研究 氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
参考文献

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Brown AM, et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar 15;507 ( Pt 3):653-65.

[3]. Barann M, et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362(3):255-65.

[4]. Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50.

[5]. Khedhaier A, et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20(6):1103-16.

[6]. Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb;20(1):78-83.

[7]. Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf. 2013 May;12(3):421-31.

 Ondansetron-d3 hydrochloride物理化学性质

分子式 C18H17D3ClN3O
分子量 296.39
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