Ondansetron HCl

• 常用名: Ondansetron HCl
• 英文名: Ondansetron Hydrochloride
• CAS号: 99614-01-4
• 分子量: 329.824
• 密度: 1.27g/cm3
• 沸点: 546ºC at 760mmHg
• 分子式: C₁₈H₂₀ClN₃O
• 熔点: 178.5-179.5ºC
• 闪点: 284ºC

Ondansetron HCl用途

Ondansetron盐酸盐是5-HT3受体拮抗剂，可作为化疗后止吐剂。

Ondansetron HCl名称

• 中文名: 盐酸枢复宁
• 英文名: ondansetron hydrochloride
• 中文别名: 盐酸昂丹司琼 | 帕罗西汀杂质A

Ondansetron HCl生物活性

• 描述: Ondansetron盐酸盐是5-HT3受体拮抗剂,可作为化疗后止吐剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Brown AM, et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar 15;507 ( Pt 3):653-65.

  [2]. Barann M, et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362(3):255-65.

  [3]. Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50.

  [4]. Khedhaier A, et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20(6):1103-16.

  [5]. Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb;20(1):78-83.

  [6]. Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf. 2013 May;12(3):421-31.

Ondansetron HCl物理化学性质

• 密度: 1.27g/cm3
• 沸点: 546ºC at 760mmHg
• 熔点: 178.5-179.5ºC
• 分子式: C₁₈H₂₀ClN₃O
• 分子量: 329.824
• 闪点: 284ºC
• 精确质量: 329.129486
• PSA: 39.82000
• LogP: 3.93050
• InChIKey: MKBLHFILKIKSQM-UHFFFAOYSA-N
• SMILES: Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O.Cl
• 外观性状: 白色粉末
• 储存条件: −20°C
• 水溶解性: H2O: >5 mg/mL

Ondansetron HCl安全信息

• 危害码 (欧洲): T: Toxic;
• 风险声明 (欧洲): R25
• 安全声明 (欧洲): 45-37/39-26
• 危险品运输编码: UN 2811 6
• WGK德国: 3
• RTECS号: FE6375500
• 包装等级: II
• 危险类别: 6.1(a)
• 海关编码: 29339900

Ondansetron HCl靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Confirmed inhibitors of the Choline Transporter (CHT) 来源：1043 靶标：high affinity choline transporter 1 [Homo sapiens] External Id：SAID_488997

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Ondansetron HCl英文别名

• UNII:2999F27MAD
• (R)-Ondansetron Hydrochloride Dihydrate
• 4H-CARBAZOL-4-ONE,1,2,3,9-TETRAHYDRO-9-METHYL-3-[(2-METHYL-1H-IMIDAZOL-1-YL)METHYL]-,HYDROCHLORIDE (1:1)
• 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one
• LSUREMONOETHANOLAMID
• Ondansetron HCl
• 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride
• OEA,oleoylethanolamide
• N-(Hydroxyethyl)oleamide
• 9-Methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride
• [3H]-Oleoylethanolamide
• oleic acid ethanolamide
• ONDANSETRON HCL DIHYDRATE
• 9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4h-carbazol-4-onhydrochlorid
• Ondansetron HCl (Zofran)
• 4H-carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, monohydrochloride
• oleic monoethanolamide
• Ondansetron (hydrochloride)
• ONDANSETRONHYDROCHLORIDE
• ONDANSETRON HCL DIHYDRATE IMP. E (EP): 1H-IMIDAZOLE, CRM STANDARD
• Ondansetron hydrochloride (Zofran)
• oleic acid-N-monoethanolamide
• N-(2-Hydroxyethyl)oleamide
• OEA
• Oleoylethanolamide
• [3H]-Ondansetron hydrochloride
• 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, hydrochloride (1:1)
• ODANSETRON HYDROCHLORIDE DIHYDRATE
• Ondansetron Hydrochloride
• Oleyl monoethanolamide
• OLEAMIDE MEA
• 9-méthyl-3-[(2-méthyl-1H-imidazol-1-yl)méthyl]-1,2,3,9-tétrahydro-4H-carbazol-4-one chlorhydrate
• Oleoylmonoethanolamide
• 9-Methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride (1:1)