AZD-3463

• 常用名: AZD-3463
• 英文名: AZD-3463
• CAS号: 1356962-20-3
• 分子量: 448.948
• 密度: 1.3±0.1 g/cm3
• 沸点: 723.6±70.0 °C at 760 mmHg
• 分子式: C₂₄H₂₅ClN₆O
• 熔点: N/A
• 闪点: 391.4±35.7 °C

AZD-3463用途

AZD-3463是ALK/IGF1R抑制剂。

AZD-3463名称

• 中文名: N-[4-(4-氨基-1-哌啶基)-2-甲氧基苯基]-5-氯-4-(1H-吲哚-3-基)-2-嘧啶胺
• 英文名: N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine

AZD-3463生物活性

• 描述: AZD-3463是ALK/IGF1R抑制剂。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> ALK
  信号通路 >> 自噬 >> 自噬
  信号通路 >> 蛋白酪氨酸激酶 >> IGF-1R
  研究领域 >> 癌症

AZD-3463物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 723.6±70.0 °C at 760 mmHg
• 分子式: C₂₄H₂₅ClN₆O
• 分子量: 448.948
• 闪点: 391.4±35.7 °C
• 精确质量: 448.177826
• PSA: 92.09000
• LogP: 3.11
• InChIKey: GCYIGMXOIWJGBU-UHFFFAOYSA-N
• SMILES: COc1cc(N2CCC(N)CC2)ccc1Nc1ncc(Cl)c(-c2c[nH]c3ccccc23)n1
• 外观性状: 粉末
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.693
• 储存条件: -20℃

AZD-3463靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Human ALK receptor tyrosine kinase (Type XIX RTKs: Leukocyte tyrosine kinase (LTK) re... 来源：IUPHAR-DB 靶标：ALK receptor tyrosine kinase (Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family) [Homo sapiens] External Id：1839_Human

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

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AZD-3463英文别名

• ALK/IGF1R inhibitor||AZD3463|AZD 3463
• N-[4-(4-Amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)-2-pyrimidinamine
• AZD3463
• ALK/IGF1R inhibitor
• S7106
• N-(4-(4-aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine
• CS-1382
• AZD-3463