盐酸帕洛诺司琼

• 常用名: 盐酸帕洛诺司琼
• 英文名: Palonosetron hydrochloride
• CAS号: 135729-62-3
• 分子量: 332.868
• 密度: N/A
• 沸点: 470.4ºC at 760 mmHg
• 分子式: C₁₉H₂₅ClN₂O
• 熔点: >290ºC
• 闪点: 209.5ºC
• 符号: GHS07
• 信号词: Warning

盐酸帕洛诺司琼用途

Palonosetron盐酸盐是5-HT3拮抗剂,能抑制化疗引起的恶心呕吐(CINV)。

盐酸帕洛诺司琼名称

• 中文名: 帕洛诺司琼盐酸盐
• 英文名: palonosetron hydrochloride
• 中文别名: 盐酸帕洛诺司琼

盐酸帕洛诺司琼生物活性

• 描述: Palonosetron盐酸盐是5-HT3拮抗剂,能抑制化疗引起的恶心呕吐(CINV)。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Vishnu Murthy M, Srinivas K, Kumar R, Mukkanti K. Development and validation of a stability-indicating LC method for determining palonosetron hydrochloride, its related compounds and degradation products using naphthalethyl stationary phase. J Pharm Bio

  [2]. Ajioka H, Morita F, Akizawa Y, Yoshida K, Kitamura R, Takimoto H. Pharmacological, pharmacokinetic, and clinical profile of palonosetron hydrochloride (ALOXI I.V. Injection 0.75 mg), a novel antiemetic 5-HT3-receptor antagonist.Nihon Yakurigaku Zasshi. 2

  [3]. Ruhlmann C, Herrstedt J. Palonosetron hydrochloride for the prevention of chemotherapy-induced nausea and vomiting. Expert Rev Anticancer Ther. 2010 Feb;10(2):137-48.

  [4]. Trissel LA, Trusley C, Ben M, Kupiec TC. Physical and chemical stability of palonosetron hydrochloride with five opiate agonists during simulated Y-site administration. Am J Health Syst Pharm. 2007 Jun 1;64(11):1209-13.

  [5]. Clark, Robin D.; Miller, Aaron B.; Berger, Jacob; Repke, David B.; Weinhardt, Klaus K.; Kowalczyk, Bruce A.; Eglen, Richard M.; Bonhaus, Douglas W.; Lee, Chi Ho; et al.2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformati

盐酸帕洛诺司琼物理化学性质

• 沸点: 470.4ºC at 760 mmHg
• 熔点: >290ºC
• 分子式: C₁₉H₂₅ClN₂O
• 分子量: 332.868
• 闪点: 209.5ºC
• 精确质量: 332.165527
• PSA: 23.55000
• LogP: 3.33430
• 外观性状: 白色固体
• 蒸汽压: 5.07E-09mmHg at 25°C
• 储存条件: Refrigerator

盐酸帕洛诺司琼MSDS

盐酸帕洛诺司琼MSDS英文版

盐酸帕洛诺司琼安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933990090

盐酸帕洛诺司琼海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

盐酸帕洛诺司琼英文别名

• 1H-Benz[de]isoquinolin-1-one, 2-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-, (3aS)-, hydrochloride (1:1)
• Palonosetron Hydrochloride
• RS 25259-197
• (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride (1:1)
• (3aS)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride
• (3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one,hydrochloride
• (3aS)-2-((3S)-1-Azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one Monohydrochloride
• (3aS)-2,3,3a,4,5,6-Hexahydro-2-[(3S)-3-quinuclidinyl]-1H-benz[de]isoquinolin-1-one Monohydrochloride
• MFCD07370072
• (3aS)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinoléin-1-one chlorhydrate
• (3aS)-2-(S)-1-Azabicyclo[2,2,2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(d)isoquinolin-1-one
• (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isochinolin-1-onhydrochlorid
• 1H-benz[de]isoquinolin-1-one, 2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-, (3aS)-, monohydrochloride
• (3aS)-2-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride (1:1)
• 1H-Benz[de]isoquinolin-1-one, 2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-, (3aS)-, hydrochloride (1:1)
• Palonosetron (Hydrochloride)