阿罗茶碱

• 常用名: 阿罗茶碱
• 英文名: Arofylline
• CAS号: 136145-07-8
• 分子量: 304.73200
• 密度: 1.429g/cm3
• 沸点: 562.6ºC at 760 mmHg
• 分子式: C₁₄H₁₃ClN₄O₂
• 熔点: N/A
• 闪点: 294ºC

阿罗茶碱用途

芳茶碱是一种PDE4抑制剂,有可能治疗哮喘。

阿罗茶碱名称

• 中文名: 阿罗茶碱
• 英文名: 3-(4-chlorophenyl)-1-propyl-7H-purine-2,6-dione

阿罗茶碱生物活性

• 描述: 芳茶碱是一种PDE4抑制剂,有可能治疗哮喘。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Chorostowska-Wynimko J, Kus J, Skopińska-Rózewska E. Theophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition. J Physiol Pharmacol. 2007;58 Suppl 5(Pt 1):95-103.

阿罗茶碱物理化学性质

• 密度: 1.429g/cm3
• 沸点: 562.6ºC at 760 mmHg
• 分子式: C₁₄H₁₃ClN₄O₂
• 分子量: 304.73200
• 闪点: 294ºC
• 精确质量: 304.07300
• PSA: 72.68000
• LogP: 1.93890
• InChIKey: GVTLDPJNRVMCAL-UHFFFAOYSA-N
• SMILES: CCCn1c(=O)c2[nH]cnc2n(-c2ccc(Cl)cc2)c1=O
• 蒸汽压: 1.1E-12mmHg at 25°C
• 折射率: 1.642
• 储存条件: 2-8°C，密封，干燥

阿罗茶碱靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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阿罗茶碱英文别名

• UNII-87L38AY71R
• 3-(4-chlorophenyl)-3,7-dihydro-1-propyl-1H-purine-2,6-dione
• 1-n-propyl-3-(4-chlorophenyl)-xanthine
• Arofyllin
• 3-(4-chlorophenyl)-1-propyl-3,7-dihydro-1H-purine-2,6-dione
• Arofylline (USAN/INN)
• Arofylline
• 3-(p-chlorophenyl)-1-propylxanthine
• 3,7-dihydro-3-(4-chlorophenyl)-1-propyl-1H-purine-2,6-dione