Banoxantrone dihydrochloride

• 常用名: Banoxantrone dihydrochloride
• 英文名: Banoxantrone dihydrochloride
• CAS号: 136470-65-0
• 分子量: 444.48100
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₈N₄O₆
• 熔点: N/A
• 闪点: N/A

Banoxantrone dihydrochloride用途

Banoxantron(AQ4N)作为一种典型的缺氧选择性细胞毒素,可以被还原为一种有效的拓扑异构酶II抑制剂AQ4。班诺沙酮通过iNOS依赖机制选择性地杀死缺氧细胞。Banoxantron显示出强烈的细胞毒性和缺氧选择性效应,通过辐射增强[1][2]。

Banoxantrone dihydrochloride名称

• 英文名: 2-[[4-[2-[dimethyl(oxido)azaniumyl]ethylamino]-5,8-dihydroxy-9,10-dioxoanthracen-1-yl]amino]-N,N-dimethylethanamine oxide

Banoxantrone dihydrochloride生物活性

• 描述: Banoxantron(AQ4N)作为一种典型的缺氧选择性细胞毒素,可以被还原为一种有效的拓扑异构酶II抑制剂AQ4。班诺沙酮通过iNOS依赖机制选择性地杀死缺氧细胞。Banoxantron显示出强烈的细胞毒性和缺氧选择性效应,通过辐射增强[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> 一氧化氮合酶
• 靶点:

  iNOS

• 体外研究: 班诺沙酮(20μM；90分钟)选择性诱导缺氧的 T50/80肿瘤细胞发生损伤[1]。
• 体内研究: 班诺沙酮(200mg/kg；腹腔注射; 单剂量) 在 英国国防部小鼠中显著抑制T50/80肿瘤,并诱导细胞损伤[1]。
• 参考文献:

  [1]. Hejmadi MV, et al. DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells. Br J Cancer. 1996 Feb;73(4):499-505.

  [2]. Mehibel M, et al. Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase. Oncol Rep. 2016 Apr;35(4):1925-32.

Banoxantrone dihydrochloride物理化学性质

• 分子式: C₂₂H₂₈N₄O₆
• 分子量: 444.48100
• 精确质量: 444.20100
• PSA: 157.52000
• LogP: 2.03320

Banoxantrone dihydrochloride英文别名

• Banoxantrone
• 1,4-Bis{[2-(dimethylamino)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione bis-N-oxide
• 1,4-Bis((2-(dimethylamino)ethyl)amino)-5,8-dihydroxy-9,10-anthracenedione N,N'-dioxide
• 1,4-bis{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione
• AQ4N
• 1,4-bis-{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroanthracene-9,10-dione
• 1,4-bis-(2-dimethylamino-ethylamino)-5,8-dihydroxy-anthraquinone-bis-N-oxide
• Banoxantrone [INN:BAN]
• UNII-W5H7E45YT3
• 1,4-Bis(2-(dimethylazinoyl)ethylamino)-5,8-dihydroxy-9,10-anthraquinone