Banoxantrone dihydrochloride
Modify Date: 2024-01-31 05:52:16
Banoxantrone dihydrochloride structure
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Common Name | Banoxantrone dihydrochloride | ||
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| CAS Number | 136470-65-0 | Molecular Weight | 444.48100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H28N4O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Banoxantrone dihydrochlorideBanoxantrone (AQ4N), as a prototype hypoxia selective cytotoxin, can be reduced to AQ4, a potent topoisomerase II inhibitor. Banoxantrone selectively kills hypoxic cells via an iNOS-dependent mechanism. Banoxantrone shows a potent cytotoxicity and hypoxia-selective effect enhanced by radiation[1][2]. |
| Name | 2-[[4-[2-[dimethyl(oxido)azaniumyl]ethylamino]-5,8-dihydroxy-9,10-dioxoanthracen-1-yl]amino]-N,N-dimethylethanamine oxide |
|---|---|
| Synonym | More Synonyms |
| Description | Banoxantrone (AQ4N), as a prototype hypoxia selective cytotoxin, can be reduced to AQ4, a potent topoisomerase II inhibitor. Banoxantrone selectively kills hypoxic cells via an iNOS-dependent mechanism. Banoxantrone shows a potent cytotoxicity and hypoxia-selective effect enhanced by radiation[1][2]. |
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| Related Catalog | |
| Target |
iNOS |
| In Vitro | Banoxantrone (20 μM; 90 min) 选择性诱导缺氧的 T50/80 肿瘤细胞发生损伤[1]。 |
| In Vivo | Banoxantrone (200 mg/kg; 腹腔注射; 单剂量) 在 BDF 小鼠中显著抑制T50/80肿瘤，并诱导细胞损伤[1]。 |
| References |
| Molecular Formula | C22H28N4O6 |
|---|---|
| Molecular Weight | 444.48100 |
| Exact Mass | 444.20100 |
| PSA | 157.52000 |
| LogP | 2.03320 |
| Banoxantrone |
| 1,4-Bis{[2-(dimethylamino)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione bis-N-oxide |
| 1,4-Bis((2-(dimethylamino)ethyl)amino)-5,8-dihydroxy-9,10-anthracenedione N,N'-dioxide |
| 1,4-bis{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione |
| AQ4N |
| 1,4-bis-{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroanthracene-9,10-dione |
| 1,4-bis-(2-dimethylamino-ethylamino)-5,8-dihydroxy-anthraquinone-bis-N-oxide |
| Banoxantrone [INN:BAN] |
| UNII-W5H7E45YT3 |
| 1,4-Bis(2-(dimethylazinoyl)ethylamino)-5,8-dihydroxy-9,10-anthraquinone |