6,7,8,9-四氢-5-硝基-1H-苯[g]吲哚-2,3-二酮 3-肟

更新时间：2025-08-26 21:19:09

6,7,8,9-四氢-5-硝基-1H-苯[g]吲哚-2,3-二酮 3-肟结构式	常用名	6,7,8,9-四氢-5-硝基-1H-苯[g]吲哚-2,3-二酮 3-肟	英文名	NS-102
	CAS号	136623-01-3	分子量	261.23300
	密度	1.74g/cm3	沸点	405.8ºC at 760mmHg
	分子式	C₁₂H₁₁N₃O₄	熔点	N/A
	MSDS	中文版美版	闪点	199.2ºC

用途

NS-102是一种选择性红藻氨酸(GluK2)受体拮抗剂。NS-102是一种有效的GluR6/7受体拮抗剂[1][2][3]。

中文名	6,7,8,9-四氢-5-硝基-1H-苯[g]吲哚-2,3-二酮 3-肟
英文名	3-(hydroxyamino)-5-nitro-6,7,8,9-tetrahydrobenzo[g]indol-2-one
英文别名	更多

描述	NS-102是一种选择性红藻氨酸(GluK2)受体拮抗剂。NS-102是一种有效的GluR6/7受体拮抗剂[1][2][3]。
相关类别	信号通路 >> 神经信号通路 >> iGluR 研究领域 >> 神经疾病信号通路 >> 跨膜转运 >> iGluR
体外研究	NS-102(10μM)和GYKI 52466(30μM)的组合可防止在缺氧和葡萄糖剥夺(OGD)期间完全丧失复合动作电位(CAP)并增加CAP面积恢复[1]。
体内研究	NS-102(20、40或80 μmol/L；在海马CA3区)显著降低七氟醚诱导的多动症[1]。
参考文献	[1]. Selva Baltan Tekkök, et al. Excitotoxic mechanisms of ischemic injury in myelinated white matter. J Cereb Blood Flow Metab. 2007 Sep;27(9):1540-52. [2]. P Liang, et al. Sevoflurane activates hippocampal CA3 kainate receptors (Gluk2) to induce hyperactivity during induction and recovery in a mouse model. Br J Anaesth. 2017 Nov 1;119(5):1047-1054. [3]. Barbara Gisabella, et al. Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia. PLoS One. 2012;7(3):e32483.

密度	1.74g/cm3
沸点	405.8ºC at 760mmHg
分子式	C₁₂H₁₁N₃O₄
分子量	261.23300
闪点	199.2ºC
精确质量	261.07500
PSA	107.51000
LogP	2.13230
蒸汽压	2.81E-08mmHg at 25°C
折射率	1.794
储存条件	2-8°C，密封，干燥

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

Selective block of recombinant glur6 receptors by NS-102, a novel non-NMDA receptor antagonist.

Eur. J. Pharmacol. 269 , 43, (1994)

The diversity of neuronal glutamate receptors continues to increase with the discovery of multiple subunits and subunit families. The significance of this potential receptor heterogeneity is unknown b...

A novel non-NMDA receptor antagonist shows selective displacement of low-affinity [3H]kainate binding.

Eur. J. Pharmacol. 246 , 195, (1993)

5-Nitro-6,7,8,9-tetrahydrobenzo[G]indole-2,3-dione-3-oxime (NS-102), a new competitive glutamate receptor antagonist displaced binding to non-N-methyl-D-aspartate (non-NMDA) binding sites with no acti...

Kainate receptor-mediated inhibition of presynaptic Ca2+ influx and EPSP in area CA1 of the rat hippocampus.

J. Physiol. 509 ( Pt 3) , 833-45, (1998)

1. The effect of a low concentration (1 microM) of kainate (kainic acid; KA) on presynaptic calcium (Ca2+) influx at the Schaffer collateral-commissural (SCC) synapse was examined in rat hippocampal s...

1H-Benz[g]indole-2,3-dione,6,7,8,9-tetrahydro-5-nitro-,3-oxime

NS 102

6,7,8,9-Tetrahydro-5-nitro-1H-benz[g]indole-2,3-dione 3-oxime