NS-102
NS-102 structure
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Common Name | NS-102 | ||
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| CAS Number | 136623-01-3 | Molecular Weight | 261.23300 | |
| Density | 1.74g/cm3 | Boiling Point | 405.8ºC at 760mmHg | |
| Molecular Formula | C12H11N3O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 199.2ºC | |
Use of NS-102NS-102 is a selective kainate (GluK2) receptors antagonist. NS-102 is a potent GluR6/7 receptor antagonist[1][2][3]. |
| Name | 3-(hydroxyamino)-5-nitro-6,7,8,9-tetrahydrobenzo[g]indol-2-one |
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| Synonym | More Synonyms |
| Description | NS-102 is a selective kainate (GluK2) receptors antagonist. NS-102 is a potent GluR6/7 receptor antagonist[1][2][3]. |
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| Related Catalog | |
| In Vitro | Combination of NS-102 (10 μM) and GYKI 52466 (30 μM) preventes full loss of compound action potentials (CAPs) during oxygen and glucose deprivation (OGD) and increased CAP area recovery[1]. |
| In Vivo | NS-102 (20, 40 or 80 μmol/litre ; in the hippocampal CA3 region) significantly reduces Sevoflurane-induced hyperactivities[1]. |
| References |
| Density | 1.74g/cm3 |
|---|---|
| Boiling Point | 405.8ºC at 760mmHg |
| Molecular Formula | C12H11N3O4 |
| Molecular Weight | 261.23300 |
| Flash Point | 199.2ºC |
| Exact Mass | 261.07500 |
| PSA | 107.51000 |
| LogP | 2.13230 |
| Vapour Pressure | 2.81E-08mmHg at 25°C |
| Index of Refraction | 1.794 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Selective block of recombinant glur6 receptors by NS-102, a novel non-NMDA receptor antagonist.
Eur. J. Pharmacol. 269 , 43, (1994) The diversity of neuronal glutamate receptors continues to increase with the discovery of multiple subunits and subunit families. The significance of this potential receptor heterogeneity is unknown b... |
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A novel non-NMDA receptor antagonist shows selective displacement of low-affinity [3H]kainate binding.
Eur. J. Pharmacol. 246 , 195, (1993) 5-Nitro-6,7,8,9-tetrahydrobenzo[G]indole-2,3-dione-3-oxime (NS-102), a new competitive glutamate receptor antagonist displaced binding to non-N-methyl-D-aspartate (non-NMDA) binding sites with no acti... |
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Kainate receptor-mediated inhibition of presynaptic Ca2+ influx and EPSP in area CA1 of the rat hippocampus.
J. Physiol. 509 ( Pt 3) , 833-45, (1998) 1. The effect of a low concentration (1 microM) of kainate (kainic acid; KA) on presynaptic calcium (Ca2+) influx at the Schaffer collateral-commissural (SCC) synapse was examined in rat hippocampal s... |
| 1H-Benz[g]indole-2,3-dione,6,7,8,9-tetrahydro-5-nitro-,3-oxime |
| NS 102 |
| 6,7,8,9-Tetrahydro-5-nitro-1H-benz[g]indole-2,3-dione 3-oxime |