PD 123319 二(三氟乙酸盐)

• 常用名: PD 123319 二(三氟乙酸盐)
• 英文名: PD123319 di(trifluoroacetate)
• CAS号: 136676-91-0
• 分子量: 736.657
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₅H₃₄F₆N₄O₇
• 熔点: N/A
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

PD 123319 二(三氟乙酸盐)用途

PD 123319 ditrifluoroacetate 是一种有效的,选择性的 AT2 angiotensin II receptor 拮抗剂,IC50 值为 34 nM。

PD 123319 二(三氟乙酸盐)名称

• 中文名: PD 123319 二(三氟乙酸盐)
• 英文名: PD 123319 bistrifluoroacetate

PD 123319 二(三氟乙酸盐)生物活性

• 描述: PD 123319 ditrifluoroacetate 是一种有效的,选择性的 AT2 angiotensin II receptor 拮抗剂,IC50 值为 34 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体
  研究领域 >> 心血管疾病
• 靶点实验:

  IC50: 34 nM (AT2 Receptor)[1]

• 体外研究: PD 123319显示出在许多不同组织中区分AII受体的两个亚类。 125I-AII在牛肾上腺肾小球细胞的膜制剂中特异性标记AII的两类结合位点。第一类(DuP-753敏感)代表AII总结合位点的约85％,并且对DuP-753具有高亲和力(IC50为92.9nM)。 PD-123319对125I-AII与该位点的结合没有任何影响。第二类结合位点对PD-123319更敏感,IC50为6.9 nM,对DuP-753的亲和力低得多(IC50约为10 microM)[2]。
• 参考文献:

  [1]. Blankley CJ, et al. Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J Med Chem. 1991 Nov;34(11):3248-60.

  [2]. Boulay G, et al. Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol Pharmacol. 1992 Apr;41(4):809-15

  [3]. Estrup TM, et al. No effect of angiotensin II AT(2)-receptor antagonist PD 123319 on cerebral blood flow autoregulation. J Renin Angiotensin Aldosterone Syst. 2001 Sep;2(3):188-92.

  [4]. Brillante DG, et al. Effects of intravenous PD 123319 on haemodynamic and arterial stiffness indices in healthy volunteers. J Renin Angiotensin Aldosterone Syst. 2005 Sep;6(2):102-6.

PD 123319 二(三氟乙酸盐)物理化学性质

• 分子式: C₃₅H₃₄F₆N₄O₇
• 分子量: 736.657
• 精确质量: 736.233154
• PSA: 115.97000
• LogP: 5.04700
• InChIKey: GPKQIEZLHVGJQH-ZXVJYWQYSA-N
• SMILES: Cc1cc(Cn2cnc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N(C)C.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
• 储存条件: 2-8℃

PD 123319 二(三氟乙酸盐)安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危险品运输编码: NONH for all modes of transport

PD 123319 二(三氟乙酸盐)靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Effect on [3H]thymidine incorporation into PC12 cells expressing AT2 receptors at 10 ... 来源：ChEMBL 靶标：Type-2 angiotensin II receptor External Id：CHEMBL836705

实验名称：Displacement of [125I]angiotensin 2 from AT2 receptor in pig uterus membrane after 1.... 来源：ChEMBL 靶标：Type-2 angiotensin II receptor External Id：CHEMBL1167160

实验名称：Displacement of [125I]angiotensin 2 from AT1 receptor in rat liver membrane after 2 h... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1167159

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Effect on neurite outgrowth in mouse/rat NG108-15 cells assessed as morphological cha... 来源：ChEMBL 靶标：NG108-15 External Id：CHEMBL2091222

实验名称：Confirmatory qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12... 来源：NCGC External Id：12hLO-f-round2

实验名称：Inhibitory activity at Angiotensin II type 2 receptor. 来源：ChEMBL 靶标：Type-2 angiotensin II receptor External Id：CHEMBL643589

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PD 123319 二(三氟乙酸盐)英文别名

• (S)-1-<<4-(dimethylamino)-3-methylphenyl>methyl>-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo<4,5-c>pyridine-6-carboxylic acid
• (6S)-1-[4-(Dimethylamino)-3-methylbenzyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid trifluoroacetate (1:2)
• S-(+)-1-[(4-(dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate)
• 1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-, (6S)-, compd. with 2,2,2-trifluoroacetic acid (1:2)
• (3S)-9-[(4-DIMETHYLAMINO-3-METHYL-PHENYL)METHYL]-4-(2,2-DIPHENYLACETYL)-4,7,9-TRIAZABICYCLO[4.3.0]NONA-7,10-DIENE-3-CARBOXYLIC ACID
• 1-((4-(Dimethylamino)-3-methylphenyl)methyl)-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4.5-c]pyridine-6-carboxyli
• PD 123,319 DITRIFLUOROACETATE
• pd 123,319 di(trifluoroacetate) salt
• S-(+)-1-((4-(dimethylamino)-3-methylphenyl)methyl)-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazol(4,5-c)pyridine-6-carboxylic acid
• (S)-1-((4-(dimethylamino)-3-methylphenyl)methyl)-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo(4,5-c)pyridine-6-carboxylic acid,difluoroacetate salt
• (6S)-1-[4-(Dimethylamino)-3-methylbenzyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid
• (S)-1-{[4-(dimethylamino)-3-methylphenyl]methyl}-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid
• PD 123,319
• (S)-1-{[4-(dimethylamino)-3-methylphenyl]methyl}-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo-[4,5-c]pyridine-6-carboxylic acid,ditrifluoroacetate,dihydrate
• PD 123319 (ditrifluoroacetate)