贝西沙星

• 常用名: 贝西沙星
• 英文名: Besifloxacin
• CAS号: 141388-76-3
• 分子量: 393.84
• 密度: 1.5±0.1 g/cm3
• 沸点: 607.0±55.0 °C at 760 mmHg
• 分子式: C₁₉H₂₁ClFN₃O₃
• 熔点: N/A
• 闪点: 320.9±31.5 °C

贝西沙星用途

贝西沙星是一种氟喹诺酮类抗菌剂。贝西沙星可抑制单核细胞产生细胞因子。贝西沙星具有广谱抗菌活性[1]。

贝西沙星名称

• 中文名: (R)-7-(3-氨基六氢-1H-氮杂卓-1-基)-8-氯-1-环丙基-6-氟-1,4-二氢-4-氧代-3-喹啉甲酸
• 英文名: 7-[(3R)-3-aminoazepan-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid
• 中文别名: 贝西沙星

贝西沙星生物活性

• 描述: 贝西沙星是一种氟喹诺酮类抗菌剂。贝西沙星可抑制单核细胞产生细胞因子。贝西沙星具有广谱抗菌活性[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  Bacteria[1]

• 参考文献:

  [1]. Zhang JZ, et al. Besifloxacin, a novel fluoroquinolone antimicrobial agent, exhibits potent inhibition of pro-inflammatory cytokines in human THP-1 monocytes. J Antimicrob Chemother. 2008;61(1):111-116.

贝西沙星物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 607.0±55.0 °C at 760 mmHg
• 分子式: C₁₉H₂₁ClFN₃O₃
• 分子量: 393.84
• 闪点: 320.9±31.5 °C
• 精确质量: 393.125549
• PSA: 88.56000
• LogP: 1.91
• InChIKey: QFFGVLORLPOAEC-SNVBAGLBSA-N
• SMILES: NC1CCCCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.649
• 储存条件: -20°C

贝西沙星安全信息

• 危害码 (欧洲): Xn

贝西沙星靶点实验

查看更多实验

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HR... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303810

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Antibacterial activity against Serratia marcescens by CLSI M7-A7 method 来源：ChEMBL 靶标：Serratia marcescens External Id：CHEMBL1667015

实验名称：Antibacterial activity against non-levofloxacin susceptible Stenotrophomonas maltophi... 来源：ChEMBL 靶标：Stenotrophomonas maltophilia External Id：CHEMBL1667016

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贝西沙星英文别名

• QCR-76
• 7-[(3R)-3-Amino-1-azepanyl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
• Besifloxacin [INN]
• BFE2NBZ7NX
• UNII-BFE2NBZ7NX
• Besivance
• (R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• Besifloxacin