141388-76-3

• 常用中文名：贝西沙星
• 常用英文名：Besifloxacin
• CAS号：141388-76-3
• 分子式：C₁₉H₂₁ClFN₃O₃
• 分子量：393.84
• 相关类别： 原料药 人工合成抗感染类药 喹诺酮类药
• 发布时间：2018-11-22 22:21:14
• 更新时间：2026-07-09 15:50:31
• 贝西沙星是一种氟喹诺酮类抗菌剂。贝西沙星可抑制单核细胞产生细胞因子。贝西沙星具有广谱抗菌活性[1]。

名称

• 中文名: (R)-7-(3-氨基六氢-1H-氮杂卓-1-基)-8-氯-1-环丙基-6-氟-1,4-二氢-4-氧代-3-喹啉甲酸
• 英文名: 7-[(3R)-3-aminoazepan-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid
• 中文别名: (R)-7-(3-氨基六氢-1H-氮杂环庚烯-1-基)-8-氯-1-环丙基-6-氟-1,4-二氢-4-氧代-喹啉-3-甲酸
• 英文别名: QCR-76; 7-[(3R)-3-aminoazan-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-cboxylic acid; Besifloxacin //BP; (R)-7-(3-Aminohexahydro-1H-azin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinolinecboxylic acid; 3-Quinolinecboxylic acid, 7-[(3R)-3-aMinohexahydro-1H-azin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo; 7-[(3R)-3-Amino-1-azanyl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecboxylic acid; Besifloxacin [INN]; (R)-7-(3-aMinoazan-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-cboxylic acid; Besivence; 3-Quinolinecboxylicacid,7-[(3R)-3-aMinohexahydro-1H-azin-1-y; (R)-7-(3-Aminohexahydro-1H-azin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecboxylic acid; Besivance; (R)-7-(3-Aminohexahydro-1H-azin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-qu; (R)-7-(3-Aminohexahydro-1H-azin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecboxylic acid //BP; Levetiracetam Impurity 50; 7-[(3R)-3-Amino-1-azepanyl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; 7-[(3R)-3-aminoazan-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-cboxylic acid; BFE2NBZ7NX; UNII-BFE2NBZ7NX; (R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 607.0±55.0 °C at 760 mmHg
• 分子式: C₁₉H₂₁ClFN₃O₃
• 分子量: 393.84
• 闪点: 320.9±31.5 °C
• 精确质量: 393.125549
• PSA: 88.56000
• LogP: 1.91
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.649
• 储存条件: -20°C

生物活性

• 描述: 贝西沙星是一种氟喹诺酮类抗菌剂。贝西沙星可抑制单核细胞产生细胞因子。贝西沙星具有广谱抗菌活性[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点:

  Bacteria[1]

• 参考文献:

  [1]. Zhang JZ, et al. Besifloxacin, a novel fluoroquinolone antimicrobial agent, exhibits potent inhibition of pro-inflammatory cytokines in human THP-1 monocytes. J Antimicrob Chemother. 2008;61(1):111-116.

安全

• 危害码 (欧洲): Xn