培氟沙星

更新时间：2025-08-20 12:36:41

培氟沙星结构式	常用名	培氟沙星	英文名	Pefloxacin mesylate dihydrate
	CAS号	149676-40-4	分子量	465.49400
	密度	N/A	沸点	529.1ºC at 760mmHg
	分子式	C₁₈H₂₈FN₃O₈S	熔点	271ºC
	MSDS	中文版美版	闪点	273.8ºC
	符号	GHS07	信号词	Warning

培氟沙星用途

去水甲磺酸Pefloxacin是抗菌素,能通过抑制DNA旋转酶阻断细菌DNA复制。

中文名	培氟沙星
英文名	Pefloxacin mesylate dihydrate
中文别名	盐酸地布卡因 \| 1-乙基-6-氟-7-(4-甲基哌嗪-1-基)-4-氧代喹啉-3-羧酸 \| 1-乙基-6-氟-7-(4-甲基哌嗪基)-4-氧代-1,4-二氢喹啉-3-羧酸甲磺酸盐
英文别名	更多

描述	去水甲磺酸Pefloxacin是抗菌素,能通过抑制DNA旋转酶阻断细菌DNA复制。
相关类别	信号通路 >> 抗感染 >> 细菌研究领域 >> 感染
参考文献	[1]. Drlica K, et al. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. [2]. Hussy P, et al. Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8.

描述

去水甲磺酸Pefloxacin是抗菌素,能通过抑制DNA旋转酶阻断细菌DNA复制。

相关类别

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

参考文献

[1]. Drlica K, et al. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92.

[2]. Hussy P, et al. Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8.

沸点	529.1ºC at 760mmHg
熔点	271ºC
分子式	C₁₈H₂₈FN₃O₈S
分子量	465.49400
闪点	273.8ºC
精确质量	465.15800
PSA	146.99000
LogP	2.06960
InChIKey	LEULAXMUNMRLPW-UHFFFAOYSA-N
SMILES	CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(C)CC3)cc21.CS(=O)(=O)O.O.O
外观性状	白色粉末
储存条件	Store at?0-5°C

符号	GHS07
信号词	Warning
危害声明	H319
警示性声明	P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xn
风险声明 (欧洲)	22-36
安全声明 (欧洲)	26
危险品运输编码	NONH for all modes of transport
RTECS号	VB2002200

Pefloxacin-induced achilles tendon toxicity in rodents: biochemical changes in proteoglycan synthesis and oxidative damage to collagen.

Antimicrob. Agents Chemother. 44 , 867-872, (2000)

Despite a relatively low incidence of serious side effects, fluoroquinolones and the fluoroquinolone pefloxacin have been reported to occasionally promote tendinopathy that might result in the complic...

Cytotoxicity and uptake of pefloxacin, ciprofloxacin, and ofloxacin in primary cultures of rat hepatocytes.

J. Antimicrob. Chemother. 24 , 355-363, (1989)

The cytotoxicity and the uptake of three 4-quinolones--pefloxacin, ciprofloxacin, and ofloxacin--were investigated in primary cultures of rat hepatocytes. As assessed by intracellular enzyme release i...

实验名称：Identifying Sarm1 Tir Hydrolase inhibitors through NAD-Glo assay
来源：24386
靶标：N/A
External Id：Sarm1 Tir NADase inhibitors screen

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：HCMV UL50
External Id：HMS1262

实验名称：MELAS cybrid survival enhancement under low glucose conditions
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：N/A
External Id：HMS1419

实验名称：Stabilization of p53 in human papillomavirus-positive cells
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：Cellular tumor antigen p53
External Id：HMS1485

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MFCD01685696

1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,methanesulfonic acid,dihydrate

EINECS 274-613-9

Pefloxacin mesilate dihydrate

3-Quinolinecarboxylic acid (1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo