2-MPMDQ

• 常用名: 2-MPMDQ
• 英文名: 2-MPMDQ
• CAS号: 149847-77-8
• 分子量: 405.49
• 密度: 1.3±0.1 g/cm3
• 沸点: 578.2±60.0 °C at 760 mmHg
• 分子式: C₂₃H₂₇N₅O₂
• 熔点: N/A
• 闪点: 303.5±32.9 °C

2-MPMDQ用途

2-MPMDQ是一种有效且选择性的α1-肾上腺素受体(Ki=0.37 nM)拮抗剂,优于α2-肾上腺素受体(Ki=1740 nM)。2-MPMDQ是一种强效降压药,具有高血压研究的潜力[1]。

2-MPMDQ名称

• 英文名: 2-{[4-(2-Methoxyphenyl)-1-piperazinyl]methyl}-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one

2-MPMDQ生物活性

• 描述: 2-MPMDQ是一种有效且选择性的α1-肾上腺素受体(Ki=0.37 nM)拮抗剂,优于α2-肾上腺素受体(Ki=1740 nM)。2-MPMDQ是一种强效降压药,具有高血压研究的潜力[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
• 靶点实验:

  α1-adrenergic receptor:0.37 nM (Ki)

  α2-adrenergic receptor:1740 nM (Ki)

• 参考文献:

  [1]. J W Chern, et al. Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. J Med Chem. 1993 Jul 23;36(15):2196-207.

2-MPMDQ物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 578.2±60.0 °C at 760 mmHg
• 分子式: C₂₃H₂₇N₅O₂
• 分子量: 405.49
• 闪点: 303.5±32.9 °C
• 精确质量: 405.216461
• LogP: 1.60
• InChIKey: OULFYKAESNCMFJ-UHFFFAOYSA-N
• SMILES: COc1ccccc1N1CCN(CC2CN3C(=O)N(C)c4ccccc4C3=N2)CC1
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.676

2-MPMDQ靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (E... 来源：NCGC External Id：epac1-activator-v

实验名称：Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 3... 来源：NCGC External Id：epac1-inhibitor-v

实验名称：Blood pressure lowering activity in spontaneously hypertensive rats (SHR) after 6 hou... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL790228

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (E... 来源：NCGC External Id：epac2-activator-v2

实验名称：Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 4... 来源：NCGC External Id：epac2-inhibitor-v2

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2mCherry

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Ratio of binding affinity against alpha-2 adrenoceptor to that of alpha-1 adrenocepto... 来源：ChEMBL 靶标：Alpha-2A adrenergic receptor External Id：CHEMBL849971

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2-MPMDQ英文别名

• 2-{[4-(2-Methoxyphenyl)-1-piperazinyl]methyl}-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one
• 2-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one