哌波色罗

• 常用名: 哌波色罗
• 英文名: Piboserod
• CAS号: 152811-62-6
• 分子量: 369.50000
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₃₁N₃O₂
• 熔点: N/A
• 闪点: N/A
• 符号: GHS06
• 信号词: Danger

哌波色罗用途

Piboserod (SB 207266)是5-羟色胺受体5-HT4选择性抑制剂。

哌波色罗名称

• 中文名: N-[(1-丁基-4-哌啶基)甲基]-3,4-二氢-2H-[1,3]噁嗪并[3,2-a]吲哚-10-羧胺
• 英文名: N-[(1-butylpiperidin-4-yl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide

哌波色罗生物活性

• 描述: Piboserod (SB 207266)是5-羟色胺受体5-HT4选择性抑制剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Darblade B, et al. Piboserod (SB 207266), a selective 5-HT4 receptor antagonist, reduces serotonin potentiation of neurally-mediated contractile responses of human detrusor muscle. World J Urol. 2005 Jun;23(2):147-51.

  [2]. Kjekshus JK, et al. Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. Eur J Heart Fail. 2009 Aug;11(8):771-8.

  [3]. Nirogi R, et al. In-vivo rat striatal 5-HT4 receptor occupancy using non-radiolabelled SB207145. J Pharm Pharmacol. 2013 May;65(5):704-12.

哌波色罗物理化学性质

• 分子式: C₂₂H₃₁N₃O₂
• 分子量: 369.50000
• 精确质量: 369.24200
• PSA: 46.50000
• LogP: 3.99450
• InChIKey: KVCSJPATKXABRQ-UHFFFAOYSA-N
• SMILES: CCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1
• 储存条件: 2-8℃

哌波色罗安全信息

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301
• 警示性声明: P301 + P310 + P330
• 危险品运输编码: UN 2811 6.1 / PGIII

哌波色罗靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Lipophilicity, log D of the compound at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL3367330

实验名称：Antagonist activity against human 5HT4b receptor expressed in HEK293 cells assessed a... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 4 External Id：CHEMBL3367332

实验名称：Displacement of [3H]GR113808 from human 5HT4b receptor expressed in HEK293 cell membr... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 4 External Id：CHEMBL3367331

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_L363-m4-1

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哌波色罗英文别名

• Piboserod
• UNII-4UQ3S81B25