蓓萨罗丁中间体4

• 常用名: 蓓萨罗丁中间体4
• 英文名: LG-100064
• CAS号: 153559-46-7
• 分子量: 350.45100
• 密度: 1.095
• 沸点: 491.367ºC at 760 mmHg
• 分子式: C₂₃H₂₆O₃
• 熔点: N/A
• 闪点: N/A

蓓萨罗丁中间体4用途

LG-100064 是一种类视黄醇 X 受体 (retinoid-X-receptor (RXR)) 激动剂,对 RXRα,RXRβ 和 RXRγ 的 EC50 值分别为 330 nM,200 nM 和 260 nM；LG-100064 可用于癌症研究。

蓓萨罗丁中间体4名称

• 中文名: 4-[(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)羰基]苯甲酸
• 英文名: 4-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalene-2-carbonyl)benzoic acid
• 中文别名: 蓓萨罗丁中间体4

蓓萨罗丁中间体4生物活性

• 描述: LG-100064 是一种类视黄醇 X 受体 (retinoid-X-receptor (RXR)) 激动剂,对 RXRα,RXRβ 和 RXRγ 的 EC50 值分别为 330 nM,200 nM 和 260 nM；LG-100064 可用于癌症研究。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> RAR/RXR
  研究领域 >> 癌症
• 靶点实验:

  EC50: 330 nM (RXRα), 200 nM (RXRβ), 260 nM (RXRγ)[1]

• 体外研究: LG-100064(3-甲基-TTNCB)是类视黄醇-X-受体(RXR)激动剂,对于RXRα,RXRβ和RXRγ,EC50为330nM,200nM和260nM。 LG-100064对RARα/β/γ没有影响(EC50,> 10000 nM)[1]。
• 参考文献:

  [1]. Marcus F. Boehm, et al. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors.

蓓萨罗丁中间体4物理化学性质

• 密度: 1.095
• 沸点: 491.367ºC at 760 mmHg
• 分子式: C₂₃H₂₆O₃
• 分子量: 350.45100
• 精确质量: 350.18800
• PSA: 54.37000
• LogP: 5.27320
• InChIKey: QADGBOQVBUXZKO-UHFFFAOYSA-N
• SMILES: Cc1cc2c(cc1C(=O)c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.558
• 储存条件: 室温，干燥

蓓萨罗丁中间体4安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2918300090

蓓萨罗丁中间体4海关

• 海关编码: 2918300090
• 中文概述: 2918300090 其他含醛基或酮基不含其他含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

蓓萨罗丁中间体4靶点实验

查看更多实验

实验名称：Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a compe... 来源：ChEMBL 靶标：Retinoic acid receptor RXR-alpha External Id：CHEMBL797916

实验名称：Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR alpha 来源：ChEMBL 靶标：Retinoic acid receptor alpha External Id：CHEMBL799797

实验名称：Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated... 来源：ChEMBL 靶标：Retinoic acid receptor RXR-gamma External Id：CHEMBL798968

实验名称：Relative activity against Retinoic acid receptor RXR-alpha at 10e-6 M retinoid relati... 来源：ChEMBL 靶标：Retinoic acid receptor RXR-alpha External Id：CHEMBL807183

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Inhibition of [3H]9-cis-RA binding to baculovirus expressed retinoid receptor RXR gam... 来源：ChEMBL 靶标：Retinoic acid receptor RXR-gamma External Id：CHEMBL800761

实验名称：Mutagenic activity in Saccharomyces cerevisiae after 3 hrs 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL1062042

实验名称：Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV... 来源：ChEMBL 靶标：Retinoic acid receptor RXR-gamma External Id：CHEMBL800759

实验名称：Transcriptional activity was evaluated in CV-1 cells transfected with expression vect... 来源：ChEMBL 靶标：Retinoic acid receptor RXR-alpha External Id：CHEMBL807369

实验名称：Effective concentration against Retinoic acid receptor RXR-alpha 来源：ChEMBL 靶标：Retinoic acid receptor RXR-alpha External Id：CHEMBL807368

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蓓萨罗丁中间体4英文别名

• Benzoic acid,4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]
• 4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)benzoic acid
• 4-[(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoic acid
• 4-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl]benzoic acid
• 3-Methyl-TTNCB
• QC-1681
• p-[3,5,5,8,8-pentamethyl-1,2,3,4-tetrahydro-2-naphthyl-(2-carbonyl)]benzoic acid
• LG-100064