OS-3-106

• 常用名: OS-3-106
• 英文名: OS-3-106
• CAS号: 1580000-17-4
• 分子量: 450.60
• 密度: 1.2±0.1 g/cm3
• 沸点: 671.3±55.0 °C at 760 mmHg
• 分子式: C₂₅H₃₀N₄O₂S
• 熔点: N/A
• 闪点: 359.8±31.5 °C

OS-3-106用途

OS-3-106是一种有效的BBB穿透选择性多巴胺D3受体(D3R)激动剂。OS-3-106在D3R处以高亲和力(Ki=0.2 nM)结合。OS-3-106降低可卡因自我给药和蔗糖强化率。OS-3-106可用于精神刺激成瘾研究[1]。

OS-3-106名称

• 英文名: N-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-4-(1,3-thiazol-4-yl)benzamide

OS-3-106生物活性

• 描述: OS-3-106是一种有效的BBB穿透选择性多巴胺D3受体(D3R)激动剂。OS-3-106在D3R处以高亲和力(Ki=0.2 nM)结合。OS-3-106降低可卡因自我给药和蔗糖强化率。OS-3-106可用于精神刺激成瘾研究[1]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 靶点实验:

  D3 Receptor:0.2 nM (Ki)

  D2 Receptor

• 体外研究: OS-3-106对D3R的结合选择性是D2R的115倍【1】。
• 参考文献:

  [1]. Cheung TH, et al. Reduction of cocaine self-administration and D3 receptor-mediated behavior by two novel dopamine D3 receptor-selective partial agonists, OS-3-106 and WW-III-55. J Pharmacol Exp Ther. 2013 Nov;347(2):410-23.

OS-3-106物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 671.3±55.0 °C at 760 mmHg
• 分子式: C₂₅H₃₀N₄O₂S
• 分子量: 450.60
• 闪点: 359.8±31.5 °C
• 精确质量: 450.208954
• LogP: 4.10
• InChIKey: RGWFVVKSJUSKTE-UHFFFAOYSA-N
• SMILES: COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cscn3)cc2)CC1
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.597

OS-3-106靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

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实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

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OS-3-106英文别名

• MFCD28118985
• N-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-4-(1,3-thiazol-4-yl)benzamide