奈非那韦

• 常用名: 奈非那韦
• 英文名: Nelfinavir
• CAS号: 159989-64-7
• 分子量: 567.78
• 密度: 1.22g/cm3
• 沸点: 786.8ºC at 760 mmHg
• 分子式: C₃₂H₄₅N₃O₄S
• 熔点: N/A
• 闪点: 429.7ºC

奈非那韦名称

• 中文名: 奈非那韦
• 英文名: nelfinavir
• 中文别名: 娜芙维亚 | 2-[(2R,3R)-2-羟基-3-[(3-羟基-2-甲基苯甲酰)氨基]-4-(苯基硫)丁基]-(3S,4aS,8aS)-N-叔丁基十氢异喹啉-3-甲酰胺

奈非那韦生物活性

• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HIV蛋白酶
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Mondal D, et al. Nelfinavir suppresses insulin signaling and nitric oxide production by human aortic endothelial cells: protective effects of thiazolidinediones. Ochsner J. 2013 Spring;13(1):76-90.

  [2]. Kaldor SW, et al. Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. J Med Chem. 1997 Nov 21;40(24):3979-85.

奈非那韦物理化学性质

• 密度: 1.22g/cm3
• 沸点: 786.8ºC at 760 mmHg
• 分子式: C₃₂H₄₅N₃O₄S
• 分子量: 567.78
• 闪点: 429.7ºC
• PSA: 189.95000
• LogP: 6.05210
• InChIKey: QAGYKUNXZHXKMR-HKWSIXNMSA-N
• SMILES: Cc1c(O)cccc1C(=O)NC(CSc1ccccc1)C(O)CN1CC2CCCCC2CC1C(=O)NC(C)(C)C
• 外观性状: 白色至灰白色结晶粉末
• 蒸汽压: 4.38E-26mmHg at 25°C
• 折射率: 1.618
• 储存条件: 2-8℃

奈非那韦靶点实验

查看更多实验

实验名称：Ratio of Kcat to Km for HIV1 recombinant protease V32I/I47A mutant 来源：ChEMBL 靶标：Pol polyprotein External Id：CHEMBL982093

实验名称：Ratio of Kcat to Km for HIV1 recombinant protease A71V/V82T/I84V mutant 来源：ChEMBL 靶标：Pol polyprotein External Id：CHEMBL982092

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Ratio of Kcat to Km for HIV1 recombinant protease L10I/I15V/E35D/N37S/R41K/I62V/L63P/... 来源：ChEMBL 靶标：N/A External Id：CHEMBL982094

实验名称：Partition coefficient (logP) 来源：ChEMBL 靶标：N/A External Id：CHEMBL630098

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Colloidal aggregation in fed state simulated intestinal fluid assessed as colloid rad... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1118204

实验名称：Unbound brain-to-plasma concentration ratio in P-gp knock out Sprague-Dawley rat 来源：ChEMBL 靶标：N/A External Id：CHEMBL4823491

实验名称：Unbound brain concentration in P-gp knock out Sprague-Dawley rat at 5 mg/ml/kg, po me... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4823489

实验名称：Ratio of drug concentration in brain to plasma of P-gp knock out Sprague-Dawley rat 来源：ChEMBL 靶标：N/A External Id：CHEMBL4823490

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奈非那韦英文别名

• Methansulfonsäure--(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-{[(3-hydroxy-2-methylphenyl)carbonyl]amino}-4-(phenylsulfanyl)butyl]decahydroisochinolin-3-carboxamid(1:1)
• Nelfinavir mesylate
• Viracept (TN)
• (3S,4aS,8aS)-N-tert-Butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylsulfanyl)butyl]decahydroisoquinoline-3-carboxamide methanesulfonate (1:1)
• Nelfinavir (INN)
• Nelfinavir Monomethane Sulfonate
• Viracept
• acide méthanesulfonique - (3S,4aS,8aS)-N-(1,1-diméthyléthyl)-2-[(2R,3R)-2-hydroxy-3-{[(3-hydroxy-2-méthylphényl)carbonyl]amino}-4-(phénylsulfanyl)butyl]décahydroisoquinoléine-3-carboxamide (1:1)
• AG1343
• (3S,4AS,8AS)-2-[(2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzoylamino)-4-phenylthiobutyl]decahydroisoquinoline-3-carboxylic acid t-butylamide
• 3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-, (3S,4aS,8aS)-, methanesulfonate (1:1) (salt)
• (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]decahydroisoquinoline-3-carboxamide methanesulfonate (salt)
• [3H]-Nelfinavir
• UNII-HO3OGH5D7I
• (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-{[(3-hydroxy-2-methylphenyl)carbonyl]amino}-4-(phenylsulfanyl)butyl]decahydroisoquinoline-3-carboxamide methanesulfonate (salt)
• (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
• VRX496
• [14C]-Nelfinavir
• AZT/3TC/NLFR combination
• (3S-(2(2S*,3S*),3-a,4ab,8ab))-N-(1,1-dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hydroxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-3-isoquinolinecarboxamide monomethanesulfonate (salt)
• (3S,4aS,8aS)-2-[(2R,3R)-2-Hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylsulfanyl)butyl]-N-(2-methyl-2-propanyl)decahydro-3-isoquinolinecarboxamide methanesulfonate (1:1)
• [3S-(3R*,4AR*,8AR*,2'S*,3'S*)]-2-[2'-Hydroxy-3'-phenylthiomethyl-4'-aza-5'-oxo-5'-(2''-methyl-3''-hydroxyphenyl)pentyl]decahydroisoquinoline-3-N-t-butylcarboxamide
• 1ohr