GSK-843

• 常用名: GSK-843
• 英文名: GSK-843
• CAS号: 1601496-05-2
• 分子量: 377.49
• 密度: 1.5±0.1 g/cm3
• 沸点: 640.0±55.0 °C at 760 mmHg
• 分子式: C₁₉H₁₅N₅S₂
• 熔点: N/A
• 闪点: 340.8±31.5 °C

GSK-843用途

GSK-843 是一种受体相互作用蛋白激酶 3 (RIP3 or RIPK3) 抑制剂,高亲和力结合 RIP3 激酶结构域,IC50 值为 8.6 nM,并抑制激酶活性,IC50 值为 6.5 nM。

GSK-843名称

• 中文名: GSK-843
• 英文名: 3-(1,3-Benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine

GSK-843生物活性

• 描述: GSK-843 是一种受体相互作用蛋白激酶 3 (RIP3 or RIPK3) 抑制剂,高亲和力结合 RIP3 激酶结构域,IC50 值为 8.6 nM,并抑制激酶活性,IC50 值为 6.5 nM。
• 相关类别:
  信号通路 >> 细胞凋亡 >> RIP激酶
  研究领域 >> 炎症/免疫
• 靶点实验:

  IC50: 6.5 nM (RIP3)[1]

• 参考文献:

  [1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.

GSK-843物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 640.0±55.0 °C at 760 mmHg
• 分子式: C₁₉H₁₅N₅S₂
• 分子量: 377.49
• 闪点: 340.8±31.5 °C
• 精确质量: 377.076874
• LogP: 4.90
• InChIKey: BPKSNNJTKPIZKR-UHFFFAOYSA-N
• SMILES: Cc1cc(-c2cnc(N)c3c(-c4ccc5scnc5c4)csc23)n(C)n1
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.832
• 储存条件: -20°C，干燥，密封

GSK-843安全信息

• 危害码 (欧洲): Xi

GSK-843靶点实验

查看更多实验

实验名称：Inhibition of human PKCmu/PRKD1 using KKLNRTLSVA as substrate at 1 uM in presence of ... 来源：ChEMBL 靶标：Serine/threonine-protein kinase D1 External Id：CHEMBL5649890

实验名称：Inhibition of human PKCnu/PRKD3 using KKLNRTLSVA as substrate at 1 uM in presence of ... 来源：ChEMBL 靶标：Serine/threonine-protein kinase D3 External Id：CHEMBL5649891

实验名称：Inhibition of human PKCtheta using ERMRPRKRQGSVRRRV as substrate at 1 uM in presence ... 来源：ChEMBL 靶标：Protein kinase C theta type External Id：CHEMBL5649892

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Inhibition of human PKCzeta using ERMRPRKRQGSVRRRV as substrate at 1 uM in presence o... 来源：ChEMBL 靶标：Protein kinase C zeta type External Id：CHEMBL5649893

实验名称：Inhibition of human PKD2/PRKD2 using KKLNRTLSVA as substrate at 1 uM in presence of 3... 来源：ChEMBL 靶标：Serine/threonine-protein kinase D2 External Id：CHEMBL5649894

实验名称：Inhibition of human PKG1a using LRRASLG as substrate at 1 uM in presence of 32P-ATP b... 来源：ChEMBL 靶标：cGMP-dependent protein kinase 1 External Id：CHEMBL5649895

实验名称：Inhibition of human PKG1b using LRRASLG as substrate at 1 uM in presence of 32P-ATP b... 来源：ChEMBL 靶标：cGMP-dependent protein kinase 1 External Id：CHEMBL5649896

实验名称：Inhibition of human PKG2/PRKG2 using LRRASLG as substrate at 1 uM in presence of 32P-... 来源：ChEMBL 靶标：cGMP-dependent protein kinase 2 External Id：CHEMBL5649897

实验名称：Inhibition of human PKN1/PRK1 using KKLNRTLSVA as substrate at 1 uM in presence of 32... 来源：ChEMBL 靶标：Serine/threonine-protein kinase N1 External Id：CHEMBL5649898

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GSK-843英文别名

• 3-(1,3-Benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine