纳曲酮

• 常用名: 纳曲酮
• 英文名: naltrexone
• CAS号: 16590-41-3
• 分子量: 341.40
• 密度: 1.5±0.1 g/cm3
• 沸点: 558.1±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₃NO₄
• 熔点: 168-170ºC
• 闪点: 291.4±30.1 °C
• 符号: GHS02, GHS06, GHS08
• 信号词: Danger

纳曲酮用途

Naltrexone 是 Opioid receptor 的拮抗剂。Naltrexone 在体内抑制细胞增殖。Naltrexone 通过干扰细胞信号和改变免疫系统来抑制肿瘤生长。

纳曲酮名称

• 中文名: 纳曲酮
• 英文名: naltrexone
• 中文别名: 17-(环丙甲基)-4,5-环氧-3,14-二羟基吗啡烷-6-酮 | 纳屈酮

纳曲酮生物活性

• 描述: Naltrexone 是 Opioid receptor 的拮抗剂。Naltrexone 在体内抑制细胞增殖。Naltrexone 通过干扰细胞信号和改变免疫系统来抑制肿瘤生长。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体
  信号通路 >> 神经信号通路 >> 阿片受体
• 参考文献:

  [1]. Couto RD, et al. Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer. Curr Drug Res Rev. 2021;13(2):86-89.

  [2]. Lobmaier PP, et al. Naltrexone depot formulations for opioid and alcohol dependence: a systematic review. CNS Neurosci Ther. 2011 Dec;17(6):629-36.

  [3]. Mannelli P, Peindl KS, Wu LT. Pharmacological enhancement of naltrexone treatment for opioid dependence: a review. Subst Abuse Rehabil. 2011 Jun;2011(2):113-123.

  [4]. Swift R, Oslin DW, Alexander M, Forman R. Adherence monitoring in naltrexone pharmacotherapy trials: a systematic review. J Stud Alcohol Drugs. 2011 Nov;72(6):1012-8.

  [5]. Makowski CT, Gwinn KM, Hurren KM. Naltrexone/bupropion: an investigational combination for weight loss and maintenance. Obes Facts. 2011;4(6):489-94.

  [6]. Hulse GK. Improving Clinical Outcomes for Naltrexone as a Management of Problem Alcohol Use. Br J Clin Pharmacol. 2012 Sep 5. doi: 10.1111/j.1365-2125.2012.04452.x.

  [7]. Naltrexone

纳曲酮物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 558.1±50.0 °C at 760 mmHg
• 熔点: 168-170ºC
• 分子式: C₂₀H₂₃NO₄
• 分子量: 341.40
• 闪点: 291.4±30.1 °C
• 精确质量: 341.162720
• PSA: 70.00000
• LogP: 1.80
• InChIKey: DQCKKXVULJGBQN-XFWGSAIBSA-N
• SMILES: O=C1CCC2(O)C3Cc4ccc(O)c5c4C2(CCN3CC2CC2)C1O5
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.709
• 储存条件: 库房通风低温干燥,与氧化剂,食品分开储运

纳曲酮毒性和生态

纳曲酮安全信息

• 符号: GHS02, GHS06, GHS08
• 信号词: Danger
• 危害声明: H225-H301 + H311 + H331-H370
• 警示性声明: P210-P260-P280-P301 + P310-P311
• 危害码 (欧洲): F,T
• 风险声明 (欧洲): 11-23/24/25-39/23/24/25
• 安全声明 (欧洲): 16-36/37-45
• 危险品运输编码: UN1230 - class 3 - PG 2 - Methanol, solution

纳曲酮靶点实验

查看更多实验

实验名称：Permeability coefficient, Kp in human Caco2 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4411126

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Displacement of [3H]-DPN from recombinant human mu opioid receptor expressed in CHO-K... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL4411118

实验名称：Displacement of [3H]-DPN from recombinant human delta opioid receptor expressed in CH... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL4411119

实验名称：Displacement of [3H]-DPN from guinea pig kappa opioid receptor expressed in CHO-K1 ce... 来源：ChEMBL 靶标：Kappa-type opioid receptor External Id：CHEMBL4411120

实验名称：Antagonist activity at human recombinant mu opioid receptor expressed in CHO-K1 cell ... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL4411121

实验名称：Half life in rat liver microsomes at 3 uM 来源：ChEMBL 靶标：N/A External Id：CHEMBL4411123

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

共902条，当前第1页，共91页

1

2

3

4

5

纳曲酮英文别名

• Trexonil
• NeMexin
• (1S,5R,13R,17S)-4-(Cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0.0.0]octadeca-7(18),8,10-trien-14-on
• Depotrex
• ReVia
• en1939
• Naltrel
• en1639
• Naltrexone
• Vivitrol
• (5α)-17-(Cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-one
• Antaxone
• trexan
• (1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0.0.0]octadeca-7(18),8,10-trien-14-one
• (1S,5R,13R,17S)-4-(cyclopropylméthyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0.0.0]octadéca-7(18),8,10-trién-14-one
• celupan
• En 1639A
• Um-792
• (5a)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
• Nalorex
• Depade