AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE

更新时间：2024-01-05 13:55:39

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE结构式	常用名	AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE	英文名	Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt
	CAS号	167114-91-2	分子量	1822.12000
	密度	N/A	沸点	N/A
	分子式	C₆₄H₁₁₆N₂₂O₁₉	熔点	N/A
	MSDS	美版	闪点	N/A

用途

Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂,其IC50 值为 40 nM。

中文名	AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE
英文名	Autocamtide 2-related inhibitory peptide
英文别名	更多

描述	Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂,其IC50 值为 40 nM。
相关类别	信号通路 >> 神经信号通路 >> 蛋白激酶信号通路 >> 自噬 >> 自噬研究领域 >> 神经疾病
靶点	IC50: 40 nM (CaMKII)[1].
体外研究	研究发现,Autocamtide-2相关抑制肽(一种新的合成肽ATP)是CaM激酶II的有效抑制剂,其IC50为40nm,在Ca2+/calmodulin存在或不存在时都具有活性。在所用的分析条件下,它的效力分别是CaMK-(281-302Ala286)和KN-93的50倍和500倍。
参考文献	[1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

分子式	C₆₄H₁₁₆N₂₂O₁₉
分子量	1822.12000
精确质量	1821.07000
PSA	746.43000
LogP	8.46970
外观性状	白色粉末
储存条件	2-8°C，密封，干燥

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	20/21/22-36
安全声明 (欧洲)	22-24/25-26
危险品运输编码	NONH for all modes of transport

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Autocamtide-2-related inhibitory peptide