167114-91-2

• 常用中文名：AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE
• 常用英文名：Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt
• CAS号：167114-91-2
• 分子式：C₆₄H₁₁₆N₂₂O₁₉
• 分子量：1822.12000
• 相关类别： 信号通路 自噬 自噬
• 发布时间：2018-12-23 12:44:30
• 更新时间：2026-07-07 23:04:46
• Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂,其IC50 值为 40 nM。

名称

• 中文名: AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE
• 英文名: Autocamtide 2-related inhibitory peptide
• 中文别名: APC-CY5.5标记的皮肤T细胞虏获趋化因子抗体; PE-CY5标记的皮肤T细胞虏获趋化因子抗体; [ALA9] AUTOCAMTIDE 2肽; BIOTIN标记的皮肤T细胞虏获趋化因子抗体; 碱性磷酸酶测定试剂盒(NPP底物法-AMP缓冲液法); 未包被人胎盘碱性磷酸酶(PLAP/ALPP) elisa试剂盒-E-UNEL-H0330; ANTI-CCL27 ANTIBODY-皮肤T细胞虏获趋化因子抗体; 自身肽2相关抑制肽; 碱性磷酸酶测定试剂盒(速率法); RBITC标记的皮肤T细胞虏获趋化因子抗体; 钙调蛋白激酶底物[ALA9]AUTOCAMTIDE 2(或抑制剂多肽); BF647标记的皮肤T细胞虏获趋化因子抗体; BF700标记的皮肤T细胞虏获趋化因子抗体; CCL27 多克隆抗体-E-AB-17773; 重组人 CCL27蛋白(Trx标签)-PDEH100528; 重组人 CCL27蛋白-PKSH032195; BF350标记的皮肤T细胞虏获趋化因子抗体; PER-CY5.5标记的皮肤T细胞虏获趋化因子抗体; 重组人 CCL27蛋白-PDEH100736; Placental Alkaline Phosphatase 多克隆抗体-E-AB-14764; CY5.5标记的皮肤T细胞虏获趋化因子抗体; CY3标记的皮肤T细胞虏获趋化因子抗体; PER-CY7标记的皮肤T细胞虏获趋化因子抗体; PE-CY5.5标记的皮肤T细胞虏获趋化因子抗体; 人皮肤T细胞虏获趋化因子(CTACK) elisa试剂盒-E-EL-H6221; Alkaline Phosphatase/PLAP/ALPP 多克隆抗体(Capture/Detector)-AN000360P; BF555标记的皮肤T细胞虏获趋化因子抗体; 人 PLAP/ALPP 抗体对-E-KAB-0482; APC-CY7标记的皮肤T细胞虏获趋化因子抗体; BF750标记的皮肤T细胞虏获趋化因子抗体; 人胚胎羊膜细胞(ALP)ELISA试剂盒; 重组人 Placental Alkaline Phosphatase 1/ALPP蛋白 (His标签)-PKSH032058; Placental Alkaline Phosphatase 多克隆抗体-E-AB-10977; PACIFIC BLUE标记的皮肤T细胞虏获趋化因子抗体; CY5标记的皮肤T细胞虏获趋化因子抗体; PER标记的皮肤T细胞虏获趋化因子抗体; PE-CY7标记的皮肤T细胞虏获趋化因子抗体; 丙氨酸9]自磷酸化肽2; 人碱性磷酸酶(ALP)ELISA试剂盒 YB71785Hu; 重组人 ALPP蛋白(His标签)-PDMH100160; 抑制剂多肽H-LYS-LYS-ALA-LEU-G-G-GLN-GLU-ALA-VAL-ASP-ALA-LEU-OH; BF405标记的皮肤T细胞虏获趋化因子抗体; APC标记的皮肤T细胞虏获趋化因子抗体; AUTOCAMTIDE 2-相关抑制肽; BF594标记的皮肤T细胞虏获趋化因子抗体; HRP标记的皮肤T细胞虏获趋化因子抗体; 皮肤T细胞虏获趋化因子重组兔单抗; 重组人 CCL27/CTACK蛋白(Sumo标签)-PDEH100602; CY7标记的皮肤T细胞虏获趋化因子抗体; BF488标记的皮肤T细胞虏获趋化因子抗体; PE标记的皮肤T细胞虏获趋化因子抗体; 自磷酸化肽2相关抑制肽; 人C-C型趋化因子27(CCL27)ELISA试剂盒 YB72357Hu; AP标记的皮肤T细胞虏获趋化因子抗体; BF680标记的皮肤T细胞虏获趋化因子抗体
• 英文别名: Anti-Hamster IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in goat; Anti-Horse IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit; Anti-Porcine IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit; Anti-Rat IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in goat; Anti-Rat IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in rabbit; Anti-Mouse IgG (H+L)-Alkaline Phosphatase antibody produced in she; Anti-Hamster IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit; (ALA9)-AUTOCAMTIDE-2; Anti-Mouse IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit; Anti-Chicken IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit; Anti-SheIgG (Fc specific), highly cross adsorbed-Alkaline Phosphatase antibody produced in rabbit; Anti-HAMSTER IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit; Anti-Horse IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat; Anti-Pig IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit; Anti-Chicken IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in goat; Anti-Dog IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat; Anti-Ferret IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in goat; ALS9 AUTOCAMTIDE 2; Anti-Rat IgG (H+L)-Alkaline Phosphatase antibody produced in donkey; Anti-Cat IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat; Anti-Goat IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit; AIP [Ala9]-Autocamtide 2; Anti-Guinea Pig IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat; Anti-Chicken IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in goat; Anti-Cat IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat; Anti-Rat IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in goat; Anti-Bovine IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit; Anti-SheIgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit; Anti-Mouse IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in goat; Anti-Guinea Pig IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit; Anti-Rat IgG (H+L)-Alkaline Phosphatase antibody produced in she; Anti-Mouse IgG (H+L)-Alkaline Phosphatase antibody produced in chicken; Anti-SheIgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey; Anti-Cat IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit; Anti-Ferret IgG (γ-chain specific)-Alkaline Phosphatase antibody produced in goat; Alk Phos; Autocamtide-2-related inhibitory peptide; Anti-Goat IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey; Anti-Guinea Pig IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in goat; Anti-Rabbit IgG (H+L)-Alkaline Phosphatase antibody produced in donkey; Anti-Dog IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit; Anti-Rat IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey; Anti-Swine IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit; Anti-Horse IgG (H+L)-Alkaline Phosphatase antibody produced in goat; Anti-Bovine IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat; Anti-goat IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit; Anti-Mouse IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in rabbit; Anti-Rat IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in rabbit; Anti-Dog IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit; Anti-HAMSTER IgG (H+L)-Alkaline Phosphatase antibody produced in goat; Anti-Guinea Pig IgG (H+L)-Alkaline Phosphatase antibody produced in goat; Anti-Mouse IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit; Anti-Guinea Pig IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in goat; Anti-Cat IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit; Anti-SheIgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit; Anti-Horse IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit; Anti-Mouse IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey; Anti-Horse IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit; Anti-Rat IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit

物化性质

• 分子式: C₆₄H₁₁₆N₂₂O₁₉
• 分子量: 1822.12000
• 精确质量: 1821.07000
• PSA: 746.43000
• LogP: 8.46970
• 外观性状: 白色粉末
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂,其IC50 值为 40 nM。
• 相关类别:
  信号通路 >> 神经信号通路 >> 蛋白激酶
  信号通路 >> 自噬 >> 自噬
  研究领域 >> 神经疾病
• 靶点:

  IC50: 40 nM (CaMKII)[1].

• 体外研究: 研究发现,Autocamtide-2相关抑制肽(一种新的合成肽ATP)是CaM激酶II的有效抑制剂,其IC50为40nm,在Ca2+/calmodulin存在或不存在时都具有活性。在所用的分析条件下,它的效力分别是CaMK-(281-302Ala286)和KN-93的50倍和500倍。
• 参考文献:

  [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): 20/21/22-36
• 安全声明 (欧洲): 22-24/25-26
• 危险品运输编码: NONH for all modes of transport