FTI-277

• 常用名: FTI-277
• 英文名: FTI-277
• CAS号: 170006-73-2
• 分子量: 447.61
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₉N₃O₃S₂
• 熔点: N/A
• 闪点: N/A

FTI-277用途

FTI-277是法尼基转移酶FTase抑制剂,高效Ras CAAX肽模拟物,可抑制H-Ras和K-Ras信号转导。

FTI-277名称

• 中文名: FTI-277
• 英文名: FTI-277 trifluoroacetate salt

FTI-277生物活性

• 描述: FTI-277是法尼基转移酶FTase抑制剂,高效Ras CAAX肽模拟物,可抑制H-Ras和K-Ras信号转导。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 法呢基转移酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Cohen-Jonathan E, et al. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res. 1999 Oct;152(4):404-11.

  [2]. Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16;10(1):e0116633.

  [3]. Virtanen SS, et al. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. Cell Biol Int. 2010 Aug;34(8):815-26.

FTI-277物理化学性质

• 分子式: C₂₂H₂₉N₃O₃S₂
• 分子量: 447.61
• PSA: 194.85000
• LogP: 4.84460
• InChIKey: GKFPROVOIQKYTO-UZLBHIALSA-N
• SMILES: COC(=O)C(CCSC)NC(=O)c1ccc(NCC(N)CS)cc1-c1ccccc1
• 储存条件: 2-8℃

FTI-277安全信息

• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26

FTI-277靶点实验

查看更多实验

实验名称：SANGER: Inhibition of human NCI-H1522 cell growth in a cell viability assay. 来源：ChEMBL 靶标：NCI-H1522 External Id：CHEMBL2363474

实验名称：SANGER: Inhibition of human NCI-H1437 cell growth in a cell viability assay. 来源：ChEMBL 靶标：NCI-H1437 External Id：CHEMBL2363473

实验名称：SANGER: Inhibition of human NCI-H1436 cell growth in a cell viability assay. 来源：ChEMBL 靶标：NCI-H1436 External Id：CHEMBL2363472

实验名称：SANGER: Inhibition of human NCI-H1299 cell growth in a cell viability assay. 来源：ChEMBL 靶标：NCI-H1299 External Id：CHEMBL2363467

实验名称：SANGER: Inhibition of human NCI-H1155 cell growth in a cell viability assay. 来源：ChEMBL 靶标：NCI-H1155 External Id：CHEMBL2363465

实验名称：SANGER: Inhibition of human NCI-H1092 cell growth in a cell viability assay. 来源：ChEMBL 靶标：NCI-H1092 External Id：CHEMBL2363464

实验名称：SANGER: Inhibition of human NCI-H1417 cell growth in a cell viability assay. 来源：ChEMBL 靶标：NCI-H1417 External Id：CHEMBL2363471

实验名称：SANGER: Inhibition of human NCI-H1395 cell growth in a cell viability assay. 来源：ChEMBL 靶标：NCI-H1395 External Id：CHEMBL2363470

实验名称：SANGER: Inhibition of human NCI-H1355 cell growth in a cell viability assay. 来源：ChEMBL 靶标：NCI-H1355 External Id：CHEMBL2363469

实验名称：SANGER: Inhibition of human NCI-H1304 cell growth in a cell viability assay. 来源：ChEMBL 靶标：NCI-H1304 External Id：CHEMBL2363468

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FTI-277英文别名

• fti-277