Andrastin A

• 常用名: Andrastin A
• 英文名: Andrastin A
• CAS号: 174232-42-9
• 分子量: 486.59700
• 密度: 1.19g/cm3
• 沸点: 560.3ºC at 760 mmHg
• 分子式: C₂₈H₃₈O₇
• 熔点: N/A
• 闪点: 236.1ºC

Andrastin A用途

Andrastin是一种半萜类化合物,是一种法尼基转移酶抑制剂。Andrastin A抑制多药耐药癌症细胞中抗癌化合物的流出。Andrastin A可以从青霉属物种中分离出来[1][2]。

Andrastin A名称

• 英文名: Andrastin A

Andrastin A生物活性

• 描述: Andrastin是一种半萜类化合物,是一种法尼基转移酶抑制剂。Andrastin A抑制多药耐药癌症细胞中抗癌化合物的流出。Andrastin A可以从青霉属物种中分离出来[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 法呢基转移酶
• 参考文献:

  [1]. Nielsen KF, et al. Andrastins A-D, Penicillium roqueforti Metabolites consistently produced in blue-mold-ripened cheese. J Agric Food Chem. 2005 Apr 20;53(8):2908-13.

  [2]. Rojas-Aedo JF, et al. The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti. Front Microbiol. 2017 May 5;8:813.

Andrastin A物理化学性质

• 密度: 1.19g/cm3
• 沸点: 560.3ºC at 760 mmHg
• 分子式: C₂₈H₃₈O₇
• 分子量: 486.59700
• 闪点: 236.1ºC
• 精确质量: 486.26200
• PSA: 103.81000
• LogP: 3.86940
• InChIKey: GRBXNADBNJGZRK-GJEDHNSHSA-N
• SMILES: COC(=O)C12C(=O)C(C)C(=O)C1(C)C(C)=CC1C3(C=O)CCC(OC(C)=O)C(C)(C)C3CCC12C
• 蒸汽压: 1.39E-12mmHg at 25°C
• 折射率: 1.54

Andrastin A靶点实验

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