5-硝基-2-(4-硝基苯基)-1H-苯并咪唑

• 常用名: 5-硝基-2-(4-硝基苯基)-1H-苯并咪唑
• 英文名: 6-nitro-2-(4-nitrophenyl)-1H-benzimidazole
• CAS号: 1772-39-0
• 分子量: 284.22700
• 密度: 1.544g/cm3
• 沸点: 565.2ºC at 760mmHg
• 分子式: C₁₃H₈N₄O₄
• 熔点: N/A
• 闪点: 295.6ºC

5-硝基-2-(4-硝基苯基)-1H-苯并咪唑用途

MMP2-IN-2(化合物42)是一种有效的选择性MMP-2(基质金属蛋白酶)抑制剂,IC50为4.2μM。MMP2-IN-2还显示出对MMP-13、MMP-9和MMP-8的抑制活性,IC50值分别为12、23.3和25μM[1]。

5-硝基-2-(4-硝基苯基)-1H-苯并咪唑名称

• 中文名: 5-硝基-2-(4-硝基苯基)-1H-苯并咪唑
• 英文名: 6-nitro-2-(4-nitrophenyl)-1H-benzimidazole

5-硝基-2-(4-硝基苯基)-1H-苯并咪唑生物活性

• 描述: MMP2-IN-2(化合物42)是一种有效的选择性MMP-2(基质金属蛋白酶)抑制剂,IC50为4.2μM。MMP2-IN-2还显示出对MMP-13、MMP-9和MMP-8的抑制活性,IC50值分别为12、23.3和25μM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> MMP
• 靶点实验:

  MMP-2:4.2 ± 0.2 μM (IC50)

  MMP13:12 ± 7 μM (IC50)

  MMP-9:23.3 ± 10. μM (IC50)

  MMP-8:25 ± 10 μM (IC50)

• 参考文献:

  [1]. Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 Feb 1;28(3):115257.

5-硝基-2-(4-硝基苯基)-1H-苯并咪唑物理化学性质

• 密度: 1.544g/cm3
• 沸点: 565.2ºC at 760mmHg
• 分子式: C₁₃H₈N₄O₄
• 分子量: 284.22700
• 闪点: 295.6ºC
• 精确质量: 284.05500
• PSA: 120.32000
• LogP: 4.09270
• InChIKey: XJIPBORERCFIIP-UHFFFAOYSA-N
• SMILES: O=[N+]([O-])c1ccc(-c2nc3ccc([N+](=O)[O-])cc3[nH]2)cc1
• 蒸汽压: 8.54E-13mmHg at 25°C
• 折射率: 1.74

5-硝基-2-(4-硝基苯基)-1H-苯并咪唑安全信息

• 海关编码: 2933990090

5-硝基-2-(4-硝基苯基)-1H-苯并咪唑海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-硝基-2-(4-硝基苯基)-1H-苯并咪唑靶点实验

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5-硝基-2-(4-硝基苯基)-1H-苯并咪唑英文别名

• 5-nitro-2-(4-nitro-phenyl)-1(3)H-benzimidazole
• 5-nitro-2-(4-nitro-phenyl)-1(3)H-benzoimidazole
• 5-Nitro-2-(4-nitro-phenyl)-1H-benzoimidazole
• 2-(4-nitrophenyl)-5-nitro-1H-benzimidazole
• 5-Nitro-2-(4-nitro-phenyl)-1(3)H-benzimidazol
• 5-nitro-2-(4-nitrophenyl)-1H-benzo[d]imidazole
• 2-(4-nitrophenyl)-5-nitrobenzimidazole
• 5-nitro-2-(4-nitrophenyl)-1H-benzimidazole