(R)-(+)-2-氨基-4-羟基丁酸

• 常用名: (R)-(+)-2-氨基-4-羟基丁酸
• 英文名: NKP608
• CAS号: 177707-12-9
• 分子量: 619.985
• 密度: 1.4±0.1 g/cm3
• 沸点: 719.2±60.0 °C at 760 mmHg
• 分子式: C₃₁H₂₄ClF₆N₃O₂
• 熔点: N/A
• 闪点: 388.8±32.9 °C

(R)-(+)-2-氨基-4-羟基丁酸用途

NKP608为非肽类4-氨基哌啶衍生物,是神经激肽-1(NK-1)受体拮抗剂,IC50为2.6 nM。

(R)-(+)-2-氨基-4-羟基丁酸名称

• 中文名: (R)-(+)-2-氨基-4-羟基丁酸
• 英文名: N-[(2R,4S)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(4-chlorophenyl)methyl]piperidin-4-yl]quinoline-4-carboxamide
• 中文别名: (2R,4S)-N-[1-[3,5-双(三氟甲基)苯甲酰]-2-(4-氯苄基)哌啶-4-基]喹啉-4-甲酰胺

(R)-(+)-2-氨基-4-羟基丁酸生物活性

• 描述: NKP608为非肽类4-氨基哌啶衍生物,是神经激肽-1(NK-1)受体拮抗剂,IC50为2.6 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体
  信号通路 >> 神经信号通路 >> 神经激肽受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. El-Hashim AZ, Wyss D, Lewis C. Effect of a novel NK1 receptor selective antagonist (NKP608) on citric acid induced cough and airway obstruction. Pulm Pharmacol Ther. 2004;17(1):11-8.

  [2]. Vendruscolo LF, Takahashi RN, Brüske GR, Ramos A. Evaluation of the anxiolytic-like effect of NKP608, a NK1-receptor antagonist, in two rat strains that differ in anxiety-related behaviors. Psychopharmacology (Berl). 2003 Nov;170(3):287-93.

  [3]. Rupniak NM, Carlson EJ, Shepheard S, et al. Comparison of the functional blockade of rat substance P (NK1) receptors by GR205171, RP67580, SR140333 and NKP-608. Neuropharmacology. 2003 Aug;45(2):231-41.

  [4]. Gentsch C, Cutler M, Vassout A, et al. Anxiolytic effect of NKP608, a NK1-receptor antagonist, in the social investigation test in gerbils. Behav Brain Res. 2002 Jul 18;133(2):363-8.

  [5]. Vassout A, Veenstra S, Hauser K, et al. NKP608: a selective NK-1 receptor antagonist with anxiolytic-like effects in the social interaction and social exploration test in rats. Regul Pept. 2000 Dec 22;96(1-2):7-16.

(R)-(+)-2-氨基-4-羟基丁酸物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 719.2±60.0 °C at 760 mmHg
• 分子式: C₃₁H₂₄ClF₆N₃O₂
• 分子量: 619.985
• 闪点: 388.8±32.9 °C
• 精确质量: 619.146118
• PSA: 62.30000
• LogP: 6.74
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.614
• 储存条件: 2-8℃

(R)-(+)-2-氨基-4-羟基丁酸英文别名

• nk-608
• nkp608||nk-608
• N-[(2R,4S)-1-[3,5-Bis(trifluoromethyl)benzoyl]-2-(4-chlorobenzyl)-4-piperidinyl]-4-quinolinecarboxamide
• T66 BNJ EVM- DT6NTJ AVR CXFFF EXFFF& B1R DG &&(2R)-trans Form
• nkp608
• N-[(2R,4S)-1-[3,5-Bis(trifluoromethyl)benzoyl]-2-[(4-chlorophenyl)methyl]-4-piperidinyl]-4-quinolinecarboxamide
• cs-1077
• N-[(2R,4S)-1-[3,5-Bis(trifluoromethyl)benzoyl]-2-(4-chlorobenzyl)piperidin-4-yl]quinoline-4-carboxamide
• 4-Quinolinecarboxamide, N-[(2R,4S)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(4-chlorophenyl)methyl]-4-piperidinyl]-