CPPG

更新时间：2025-08-25 10:36:53

CPPG结构式	常用名	CPPG	英文名	CPPG
	CAS号	183364-82-1	分子量	271.20600
	密度	N/A	沸点	N/A
	分子式	C₁₁H₁₄NO₅P	熔点	N/A
	MSDS	中文版美版	闪点	N/A
	符号	GHS07	信号词	Warning

CPPG用途

CPPG ((RS)-CPPG) 是一种有效的 II/III 型 mGlu 受体拮抗剂。CPPG 对大鼠大脑皮层中的 III 组 (IC50=2.2 nM) 比对 II 组((IC50=46.2 nM) mGlu 受体有一定的选择性 (约 20 倍)。CPPG 对 I 组 mGlu 受体的作用较弱。

英文名	CPPG,(RS)-α-Cyclopropyl-4-phosphonophenylglycine
英文别名	更多

描述	CPPG ((RS)-CPPG) 是一种有效的 II/III 型 mGlu 受体拮抗剂。CPPG 对大鼠大脑皮层中的 III 组 (IC50=2.2 nM) 比对 II 组((IC50=46.2 nM) mGlu 受体有一定的选择性 (约 20 倍)。CPPG 对 I 组 mGlu 受体的作用较弱。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体研究领域 >> 神经疾病
体外研究	CPPG((RS)-CPPG能同时逆转L-AP4(IC50=2.2nm)和L-CCG-I(IC50=46.2nm)介导的forskolin刺激的成年大鼠皮层脑片环腺苷酸积累的抑制作用。CPPG是抗成年大鼠皮层II/III型mGlu受体的有效拮抗剂,对III型mGlu受体具有中等的选择性。相反,CPPG对新生大鼠皮层和培养的小脑颗粒细胞中的mGlu受体的作用较弱[1]。
参考文献	[1]. Toms NJ, et al. The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol. 1996 Nov;119(5):851-4.

分子式	C₁₁H₁₄NO₅P
分子量	271.20600
精确质量	271.06100
PSA	130.66000
LogP	0.83850
InChIKey	IGODGTDUQSMDQU-UHFFFAOYSA-N
SMILES	NC(C(=O)O)(c1ccc(P(=O)(O)O)cc1)C1CC1

符号	GHS07
信号词	Warning
危害声明	H302
危险品运输编码	NONH for all modes of transport

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CPPG

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