AY77

• 常用名: AY77
• 英文名: AY77
• CAS号: 1835734-92-3
• 分子量: 404.50
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₃₂N₄O₄
• 熔点: N/A
• 闪点: N/A

AY77用途

AY77 是一种钙偏向的 PAR2 激动剂。AY77 在 PAR2 介导的 Gq 通路激活和 β-arrestin-2 募集中的 EC50 分别为 0.17 和 2 nM。AY77 有效诱导细胞内 Ca2+ 释放。

AY77名称

• 英文名: AY77

AY77生物活性

• 描述: AY77 是一种钙偏向的 PAR2 激动剂。AY77 在 PAR2 介导的 Gq 通路激活和 β-arrestin-2 募集中的 EC50 分别为 0.17 和 2 nM。AY77 有效诱导细胞内 Ca2+ 释放。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 蛋白酶激活受体(PAR)
  研究领域 >> 炎症/免疫
• 靶点实验:

  PAR2[1]

• 参考文献:

  [1]. Klösel I, et al. Discovery of Novel Nonpeptidic PAR2 Ligands. ACS Med Chem Lett. 2020 May 22;11(6):1316-1323.

  [2]. Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12(5):1217-1226.

AY77物理化学性质

• 分子式: C₂₁H₃₂N₄O₄
• 分子量: 404.50

AY77靶点实验

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实验名称：Agonist activity at human PAR2 Y326A mutant expressed in CHO cells assessed as induct... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL4000398

实验名称：Agonist activity at human PAR2 Y156A mutant expressed in CHO cells assessed as induct... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL4000397

实验名称：Agonist activity at human PAR2 L307A mutant expressed in CHO cells assessed as induct... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL4000400

实验名称：Agonist activity at human PAR2 D228A mutant expressed in CHO cells assessed as induct... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL4000399

实验名称：Agonist activity at PAR2 in 2f-LIGRLO-NH2-desensitized human PC3 cells assessed as in... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL4000394

实验名称：Agonist activity at PAR2 in human MDA-MB-231 cells assessed as induction of chemotaxi... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL4000396

实验名称：Agonist activity at PAR2 in human MDA-MB-231 cells assessed as induction of chemotaxi... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL4000395

实验名称：Agonist activity at human PAR2 expressed in HEK293T cells assessed as induction of Ga... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL4619231

实验名称：Agonist activity at PK1-tagged PAR2 (unknown origin) expressed in HEK293 cells assess... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL4619233

实验名称：Agonist activity at human PAR2 expressed in HEK293T cells assessed as induction of Ga... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL4619232

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