hDHODH-IN-2

• 常用名: hDHODH-IN-2
• 英文名: hDHODH-IN-2
• CAS号: 183946-00-1
• 分子量: 304.34
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₆N₂O₂
• 熔点: N/A
• 闪点: N/A

hDHODH-IN-2用途

hDHODH-IN-2 是一种 Leflunomide 活性代谢物的类似物。hDHODH-IN-2 是一种人二氢乳清酸脱氢酶 hDHODH 抑制剂,具有抗炎活性。

hDHODH-IN-2名称

• 英文名: hDHODH-IN-2

hDHODH-IN-2生物活性

• 描述: hDHODH-IN-2 是一种 Leflunomide 活性代谢物的类似物。hDHODH-IN-2 是一种人二氢乳清酸脱氢酶 hDHODH 抑制剂,具有抗炎活性。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  信号通路 >> 代谢酶/蛋白酶 >> 乳酸脱氢酶
  研究领域 >> 炎症/免疫
• 体外研究: 在自组织分子场分析(SOMFA)中,hDHODH-IN-2(化合物42)对大鼠和小鼠DHODH的log 1/IC50分别为5.83和5.80。
• 参考文献:

  [1]. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93.

  [2]. Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9(2):e87960.

hDHODH-IN-2物理化学性质

• 分子式: C₁₉H₁₆N₂O₂
• 分子量: 304.34
• InChIKey: CAGGGMPTWTUYHZ-ZCXUNETKSA-N
• SMILES: N#CC(C(=O)Nc1ccc(-c2ccccc2)cc1)=C(O)C1CC1
• 储存条件: 2-8°C，密封，干燥

hDHODH-IN-2靶点实验

查看更多实验

实验名称：In vivo ability to inhibit delayed type hypersensitivity in rat at a concentration of... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL794678

实验名称：Inhibition of ubiquinone binding site of human dihydroorotate dehydrogenase 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL984852

实验名称：Inhibition of ubiquinone binding site of Plasmodium falciparum dihydroorotate dehydro... 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL984851

实验名称：In vivo ability to inhibit delayed type hypersensitivity in mouse at a concentration ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL741842

实验名称：Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouse 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL666232

实验名称：Inhibitory concentration tested against enzyme dihydroorotate dehydrogenase in rat 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL666233

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