Ciproxifan

• 常用名: Ciproxifan
• 英文名: Ciproxifan
• CAS号: 184025-18-1
• 分子量: 270.326
• 密度: 1.2±0.1 g/cm3
• 沸点: 526.9±35.0 °C at 760 mmHg
• 分子式: C₁₆H₁₈N₂O₂
• 熔点: N/A
• 闪点: 272.5±25.9 °C

Ciproxifan用途

Ciproxifan(FUB-359)是高活性的H3受体拮抗剂，IC50为9.2 nM，对其它亚型受体的亲和力较低。

Ciproxifan名称

• 中文名: 环丙基[4-[3-(1H-咪唑-5-基)丙氧基]苯
• 英文名: cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone

Ciproxifan生物活性

• 描述: Ciproxifan(FUB-359)是高活性的H3受体拮抗剂,IC50为9.2 nM,对其它亚型受体的亲和力较低。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Motawaj M, Arrang JM. Ciproxifan, a histamine H?-receptor antagonist?/?inverse agonist, modulates methamphetamine-induced sensitization in mice. Eur J Neurosci. 2011 Apr;33(7):1197-204. doi: 10.1111/j.1460-9568.2011.07618.x.

  [2]. Bardgett ME, et al. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem. 2011 Jan;95(1):64-72.

  [3]. Bardgett ME, et al. The H3 antagonist, ciproxifan, alleviates the memory impairment but enhances the motor effects of MK-801 (dizocilpine) in rats. Neuropharmacology. 2010 Nov;59(6):492-502.

  [4]. Day M, et al. Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test. Biochem Pharmacol. 2007 Apr 15;73(8):1123-34.

  [5]. Pillot C, et al. Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum. Eur J Neurosci. 2003 Jan;17(2):307-14.

Ciproxifan物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 526.9±35.0 °C at 760 mmHg
• 分子式: C₁₆H₁₈N₂O₂
• 分子量: 270.326
• 闪点: 272.5±25.9 °C
• 精确质量: 270.136841
• PSA: 54.98000
• LogP: 2.29
• 外观性状: solid | white
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.613
• 储存条件: -20℃
• 水溶解性: H2O: insoluble

Ciproxifan安全信息

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22-36/37/38-43
• 安全声明 (欧洲): 26-36/37/39
• WGK德国: 3

Ciproxifan英文别名

• Ciproxifan
• cyclopropyl 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl ketone
• Methanone, cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxy]phenyl]-
• Cyclopropylpyrrol4-[3-(1H-imidazol-4-yl)propoxy] phenylmorphomethanone
• Cyclopropyl{4-[3-(1H-imidazol-4-yl)propoxy]phenyl}methanone
• FUB-359
• cyclopropyl 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl methanone