ER 50891

• 常用名: ER 50891
• 英文名: ER 50891
• CAS号: 187400-85-7
• 分子量: 432.51300
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₂₄N₂O₂
• 熔点: N/A
• 闪点: N/A

ER 50891用途

α-501受体是一种有效的视黄酸拮抗剂。ER-50891显著减弱ATRA对BMP 2诱导的成骨细胞生成的抑制作用[1]。

ER 50891名称

• 英文名: 4-[5-(8-Isopropyl-4-phenyl-2-quinolinyl)-1H-pyrrol-2-yl]benzoic a cid

ER 50891生物活性

• 描述: α-501受体是一种有效的视黄酸拮抗剂。ER-50891显著减弱ATRA对BMP 2诱导的成骨细胞生成的抑制作用[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> RAR/RXR
• 靶点实验:

  RARα[1]

• 参考文献:

  [1]. Batran RZ, et al. New quinolone derivatives as neuropeptide S receptor antagonists: Design, synthesis, homology modeling, dynamic simulations and modulation of Gq/Gs signaling pathways. Bioorg Chem. 2021;111:104817.

ER 50891物理化学性质

• 分子式: C₂₉H₂₄N₂O₂
• 分子量: 432.51300
• 精确质量: 432.18400
• PSA: 65.98000
• LogP: 7.38550
• InChIKey: LSGNKLDHMQVTEK-UHFFFAOYSA-N
• SMILES: CC(C)c1cccc2c(-c3ccccc3)cc(-c3ccc(-c4ccc(C(=O)O)cc4)[nH]3)nc12

ER 50891靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Retinoid activity at Retinoic acid receptor gamma was evaluated relative to that of A... 来源：ChEMBL 靶标：Retinoic acid receptor gamma External Id：CHEMBL801570

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：In vitro binding affinity towards Retinoic acid receptor beta evaluated relative to t... 来源：ChEMBL 靶标：Retinoic acid receptor beta External Id：CHEMBL800444

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

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