COX-2-IN-36

• 常用名: COX-2-IN-36
• 英文名: COX-2-IN-36
• CAS号: 189954-93-6
• 分子量: 338.41900
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₂₂O₅S
• 熔点: N/A
• 闪点: N/A

COX-2-IN-36用途

COX-2-IN-36 (compound 1) 是非常有效的,特异性的 COX-2 抑制剂,其IC50 值为0.4 μM。

COX-2-IN-36名称

• 英文名: (S)-5-ethyl-5-methyl-3-(1-methylethoxy)-4-[(4-methylsulfonyl)phenyl]-3-oxolen-2-one

COX-2-IN-36生物活性

• 描述: COX-2-IN-36 (compound 1) 是非常有效的,特异性的 COX-2 抑制剂,其IC50 值为0.4 μM。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> COX
• 靶点:

  IC50: 0.4 μM (COX-2)[2].

• 参考文献:

  [1]. Lushi Tan, et al. Practical enantioselective synthesis of a COX-2 specific inhibitor. TetrahedronVolume 58, Issue 37, 9 September 2002, Pages 7403-7410.

  [2]. Yves Leblanc, et al. Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3317-20.

COX-2-IN-36物理化学性质

• 分子式: C₁₇H₂₂O₅S
• 分子量: 338.41900
• 精确质量: 338.11900
• PSA: 78.05000
• LogP: 4.03250

COX-2-IN-36英文别名

• 5(S)-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one
• 5(S)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one
• (S)-5-ethyl-3-isopropoxy-5-methyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one
• (5S)-5-ethyl-3-isopropoxy-5-methyl-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one
• (5S) 5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one
• (S)-5-Ethyl-3-isopropoxy-4-(4-methanesulfonyl-phenyl)-5-methyl-5H-furan-2-one
• (5S)-ethyl-5-methyl-4-(4-(methanesulfonyl)phenyl)-3-(2-propoxy)-(5H)-furan-2-one