羧肽酶G2(CPG2)抑制剂

• 常用名: 羧肽酶G2(CPG2)抑制剂
• 英文名: Carboxypeptidase G2 (CPG2) Inhibitor
• CAS号: 192203-60-4
• 分子量: 313.32600
• 密度: 1.43
• 沸点: N/A
• 分子式: C₁₃H₁₅NO₆S
• 熔点: N/A
• 闪点: N/A

羧肽酶G2(CPG2)抑制剂用途

Carboxypeptidase G2 (CPG2) Inhibitor是羧肽酶G2（CPG2）抑制剂，具有抗癌活性。

羧肽酶G2(CPG2)抑制剂名称

• 中文名: N-[[(4-甲氧基苯基)硫]羰基]-L-谷氨酸
• 英文名: (2S)-2-[(4-methoxyphenyl)sulfanylcarbonylamino]pentanedioic acid
• 中文别名: N-[[(4-甲氧基苯基)硫代]羰基]-L-谷氨酸

羧肽酶G2(CPG2)抑制剂生物活性

• 描述: Carboxypeptidase G2 (CPG2) Inhibitor是羧肽酶G2(CPG2)抑制剂,具有抗癌活性。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 羧
  研究领域 >> 癌症
• 参考文献:

  [1]. Khan, Tariq H.; Eno-Amooquaye, Ebun A.; Searle, Frances et al. Novel Inhibitors of Carboxypeptidase G2 (CPG2): Potential Use in Antibody-Directed Enzyme Prodrug Therapy. Journal of Medicinal Chemistry (1999), 42(6), 951-956.

  [2]. Friedlos F, Lehouritis P, Ogilvie L et al. Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy. Clin Cancer Res. 2008 Jul 1;14(13):4259-66.

  [3]. Schepelmann S, Ogilvie LM, Hedley D et al. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. Cancer Res. 2007 May 15;67(10):4949-55.

  [4]. Schepelmann S, Hallenbeck P, Ogilvie LM et al. Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2. Cancer Res. 2005 Jun 15;65(12):5003-8.

羧肽酶G2(CPG2)抑制剂物理化学性质

• 密度: 1.43
• 分子式: C₁₃H₁₅NO₆S
• 分子量: 313.32600
• 精确质量: 313.06200
• PSA: 141.72000
• LogP: 2.01930
• InChIKey: OBCGYIKABKFIQB-JTQLQIEISA-N
• SMILES: COc1ccc(SC(=O)NC(CCC(=O)O)C(=O)O)cc1
• 储存条件: -20°C，密闭，干燥

羧肽酶G2(CPG2)抑制剂靶点实验

查看更多实验

实验名称：Inhibitory activity against bacterial carboxypeptidase G2 by Dixon plot assay 来源：ChEMBL 靶标：Carboxypeptidase G2 External Id：CHEMBL873194

实验名称：The compound was evaluated for the cytotoxicity towards LS174T cells. 来源：ChEMBL 靶标：LS174T External Id：CHEMBL706504

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羧肽酶G2(CPG2)抑制剂英文别名

• CS-0824
• Carboxypeptidase G2 (CPG2) Inhibitor
• L-Glutamic acid,N-[[(4-methoxyphenyl)thio]carbonyl]
• Carboxypeptidase G2 (CPG2) Inhibitor||L-Glutamic acid,N-[[(4-methoxyphenyl)thio]carbonyl]