192203-60-4

• 常用中文名：羧肽酶G2(CPG2)抑制剂
• 常用英文名：Carboxypeptidase G2 (CPG2) Inhibitor
• CAS号：192203-60-4
• 分子式：C₁₃H₁₅NO₆S
• 分子量：313.32600
• 相关类别： 生物化工 氨基酸及其衍生物 谷氨酸类衍生物
• 发布时间：2018-12-09 18:26:09
• 更新时间：2026-07-01 09:29:49
• Carboxypeptidase G2 (CPG2) Inhibitor是羧肽酶G2（CPG2）抑制剂，具有抗癌活性。

名称

• 中文名: N-[[(4-甲氧基苯基)硫]羰基]-L-谷氨酸
• 英文名: (2S)-2-[(4-methoxyphenyl)sulfanylcarbonylamino]pentanedioic acid
• 中文别名: N-[[(4-甲氧基苯基)硫代]羰基]-L-谷氨酸; 羧肽酶G2抑制剂; G2抑制剂
• 英文别名: (2S)-2-[(4-methoxyphenyl)sulfanylcbonylamino]pentanedioicaci; Cboxyptidase G2 Inhibitor; N-[[(4-Methoxyphenyl)thio]carbonyl]-L-glutamic acid //BP; G2 INHIBITOR;L-GLUTAMIC ACID; N-[[(4-METHOXYPHENYL)THIO]carbonyl]; L-GlutaMic acid, N-[[(4-Methoxyphenyl)thio]carbonyl]; L-Glutamic acid,N-[[(4-methoxyphenyl)thio]carbonyl]; Carboxypeptidase G2 (CPG2) Inhibitor||L-Glutamic acid,N-[[(4-methoxyphenyl)thio]carbonyl]; Cboxyptidase G2 G2) Inhibitor; N-[[(4-methoxyphenyl)thio]carbonyl]; CS-0824; G2 Inhibitor; N-[[(4-Methoxyphenyl)thio]carbonyl]-L-glutamic acid

物化性质

• 密度: 1.43
• 分子式: C₁₃H₁₅NO₆S
• 分子量: 313.32600
• 精确质量: 313.06200
• PSA: 141.72000
• LogP: 2.01930
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Carboxypeptidase G2 (CPG2) Inhibitor是羧肽酶G2(CPG2)抑制剂,具有抗癌活性。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 羧
  研究领域 >> 癌症
• 参考文献:

  [1]. Khan, Tariq H.; Eno-Amooquaye, Ebun A.; Searle, Frances et al. Novel Inhibitors of Carboxypeptidase G2 (CPG2): Potential Use in Antibody-Directed Enzyme Prodrug Therapy. Journal of Medicinal Chemistry (1999), 42(6), 951-956.

  [2]. Friedlos F, Lehouritis P, Ogilvie L et al. Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy. Clin Cancer Res. 2008 Jul 1;14(13):4259-66.

  [3]. Schepelmann S, Ogilvie LM, Hedley D et al. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. Cancer Res. 2007 May 15;67(10):4949-55.

  [4]. Schepelmann S, Hallenbeck P, Ogilvie LM et al. Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2. Cancer Res. 2005 Jun 15;65(12):5003-8.