AChE/BuChE-IN-2

• 常用名: AChE/BuChE-IN-2
• 英文名: AChE/BuChE-IN-2
• CAS号: 1946008-31-6
• 分子量: 318.37
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₈N₂O₂
• 熔点: N/A
• 闪点: N/A

AChE/BuChE-IN-2用途

AChE/BuChE-IN-2(化合物5f)是一种口服活性AChE和BuChE抑制剂,其IC50值分别为0.72μM和0.16μM。AChE/BuChE-IN-2显示出与AChE的非竞争性抑制,并显示出有效的自诱导β-淀粉样蛋白(aβ)聚集抑制,IC50为62.52μM。AChE/BuChE-IN-2可穿过BBB[1]。

AChE/BuChE-IN-2名称

• 英文名: AChE/BuChE-IN-2

AChE/BuChE-IN-2生物活性

• 描述: AChE/BuChE-IN-2(化合物5f)是一种口服活性AChE和BuChE抑制剂,其IC50值分别为0.72μM和0.16μM。AChE/BuChE-IN-2显示出与AChE的非竞争性抑制,并显示出有效的自诱导β-淀粉样蛋白(aβ)聚集抑制,IC50为62.52μM。AChE/BuChE-IN-2可穿过BBB[1]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> 疼痛
• 靶点实验:

  IC50: 0.16 μM (BuChE), 0.72 μM (AChE), 62.52 μM (Aβ aggregation)[1]

• 体内研究: AChE/BuChE-IN-2(化合物5f)(20μmol/kg)显著改善东莨菪碱治疗的ICR小鼠的认知能力[1]。
• 参考文献:

  [1]. Luo W, et al. Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents. Bioorg Med Chem. 2020 Jan 1;28(1):115190.

AChE/BuChE-IN-2物理化学性质

• 分子式: C₂₀H₁₈N₂O₂
• 分子量: 318.37

AChE/BuChE-IN-2靶点实验

查看更多实验

实验名称：Toxicity in scopolamine-induced cognition deficit ICR mouse model assessed as effect ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4614061

实验名称：Inhibition of electric eel AChE 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL5339538

实验名称：Inhibition of amyloid beta 42 (unknown origin) aggregation at 20 uM relative to contr... 来源：ChEMBL 靶标：Amyloid-beta precursor protein External Id：CHEMBL5339570

实验名称：Cytotoxicity against rat PC12 cells assessed as inhibition of cell viability at 10 uM... 来源：ChEMBL 靶标：PC-12 External Id：CHEMBL4614054

实验名称：Antialzheimer activity against scopolamine-induced cognition impairment ICR mouse mod... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4614056

实验名称：Antialzheimer activity against scopolamine-induced cognition impairment ICR mouse mod... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4614058

实验名称：Antialzheimer activity against scopolamine-induced cognition deficit ICR mouse model ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4614057

实验名称：Toxicity in scopolamine-induced cognition deficit ICR mouse model assessed as effect ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4614060

实验名称：Antialzheimer activity against scopolamine-induced cognition impairment ICR mouse mod... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4614059

实验名称：Selectivity index, ratio of IC50 for electric eel AChE to IC50 for equine serum BuChE 来源：ChEMBL 靶标：N/A External Id：CHEMBL4614048

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