(S)-10-羟基喜树碱

• 常用名: (S)-10-羟基喜树碱
• 英文名: (S)-10-Hydroxycamptothecin
• CAS号: 19685-09-7
• 分子量: 364.351
• 密度: 1.6±0.1 g/cm3
• 沸点: 820.7±65.0 °C at 760 mmHg
• 分子式: C₂₀H₁₆N₂O₅
• 熔点: 265-270°C
• 闪点: 450.1±34.3 °C

(S)-10-羟基喜树碱用途

(S)-10-Hydroxycamptothecin 是临床治疗肝癌的有效试剂。

(S)-10-羟基喜树碱名称

• 中文名: 10-羟基喜树碱
• 英文名: 10-Hydroxycamptothecin
• 中文别名: 伊立替康相关物质A | (S)-10-羟基喜树碱 | 10 - 羟基喜树碱 | 羟基喜树碱 | (S)-4-乙基-4,9-二羟基-1H-吡喃并[3',4':6,7]吲嗪并[1,2-b]喹啉-3,14-(4H,12H)-二酮 | (S)-4-乙基-4,9-二羟基-1H-吡喃并[3',4':6,7]吲嗪并[1,2-B]喹啉-3,14-(4H,12H)-二酮

(S)-10-羟基喜树碱生物活性

• 描述: (S)-10-Hydroxycamptothecin 是临床治疗肝癌的有效试剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 生物碱
  研究领域 >> 癌症
• 参考文献:

  [1]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance . Journal of Drug Targeting.

  [2]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target, Early Online: 1–8

(S)-10-羟基喜树碱物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 820.7±65.0 °C at 760 mmHg
• 熔点: 265-270°C
• 分子式: C₂₀H₁₆N₂O₅
• 分子量: 364.351
• 闪点: 450.1±34.3 °C
• 精确质量: 364.105927
• PSA: 101.65000
• LogP: 1.32
• InChIKey: HAWSQZCWOQZXHI-FQEVSTJZSA-N
• SMILES: CCC1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3cc(O)ccc3nc2-1
• 外观性状: 固体;White to Yellow to Orange powder to crystal
• 蒸汽压: 0.0±3.1 mmHg at 25°C
• 折射率: 1.777
• 储存条件: -20°C Freezer
• 计算化学:

  1.疏水参数计算参考值（XlogP）:0.6

  2.氢键供体数量:2

  3.氢键受体数量:6

  4.可旋转化学键数量:1

  5.互变异构体数量:3

  6.拓扑分子极性表面积:100

  7.重原子数量:27

  8.表面电荷:0

  9.复杂度:774

  10.同位素原子数量:0

  11.确定原子立构中心数量:1

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

(S)-10-羟基喜树碱毒性和生态

(S)-10-羟基喜树碱安全信息

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2934999090

(S)-10-羟基喜树碱海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(S)-10-羟基喜树碱靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Induction of apoptosis in human MGC803 cells assessed as DNA fragmentation at 10 uM a... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL2155255

实验名称：Induction of apoptosis in human MGC803 cells assessed as condensed chromatin at 10 uM... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL2155253

实验名称：Induction of apoptosis in human MGC803 cells assessed as early and late apoptotic lev... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL2155259

实验名称：Induction of apoptosis in human MGC803 cells assessed as early and late apoptotic lev... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL2155257

实验名称：Induction of apoptosis in human MGC803 cells assessed as early and late apoptotic lev... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL2155258

实验名称：Induction of apoptosis in human MGC803 cells assessed as condensed chromatin at 10 uM... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL3377516

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Induction of apoptosis in human Bcap37 cells assessed as condensed chromatin at 10 uM... 来源：ChEMBL 靶标：Bcap37 External Id：CHEMBL3377517

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

共382条，当前第1页，共39页

1

2

3

4

5

(S)-10-羟基喜树碱英文别名

• 10-Hydroxycamptothecin
• Hydroxycamptothecine
• 10-Hydroxy camptothecin
• 10-OH-camptothecin
• 10-hydroxy-CPT
• Camptothecin,hydroxy
• MFCD00189425
• 10-Hydroxycamptochecin
• Camptothecin, 10-hydroxy
• 10-hydroxy-Camptothecin
• (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• Hydroxycamptothecin
• 10-hydroxycamptothecine
• Irinotecan Related Compound A
• HCPT
• (S)-10-Hydroxycamptothecin