Z-FA-FMK

• 常用名: Z-FA-FMK
• 英文名: Z-FA-FMK
• CAS号: 197855-65-5
• 分子量: 386.417
• 密度: 1.2±0.1 g/cm3
• 沸点: 630.5±55.0 °C at 760 mmHg
• 分子式: C₂₁H₂₃FN₂O₄
• 熔点: N/A
• 闪点: 335.1±31.5 °C

Z-FA-FMK用途

Z-FA-FMK ((1S)-Z-FA-FMK; Compound 6) 是一种广谱的卤代甲基酮抑制剂,可抑制冠状病毒 (SARS-CoV) 蛋白酶 3CL,Ki 为 25.7 μM。

Z-FA-FMK名称

• 英文名: z-phe-dl-ala-fluoromethylketone

Z-FA-FMK生物活性

• 描述: Z-FA-FMK ((1S)-Z-FA-FMK; Compound 6) 是一种广谱的卤代甲基酮抑制剂,可抑制冠状病毒 (SARS-CoV) 蛋白酶 3CL,Ki 为 25.7 μM。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> SARS冠状病毒
• 靶点实验:

  Ki: 25.7 μM (SARS Protease 3CLpro)[1]

• 参考文献:

  [1]. Usman Bacha, et al. Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro). Chem Biol Drug Des. 2008 Jul;72(1):34-49.

Z-FA-FMK物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 630.5±55.0 °C at 760 mmHg
• 分子式: C₂₁H₂₃FN₂O₄
• 分子量: 386.417
• 闪点: 335.1±31.5 °C
• 精确质量: 386.164185
• PSA: 84.50000
• LogP: 3.67
• InChIKey: ASXVEBPEZMSPHB-PKHIMPSTSA-N
• SMILES: CC(NC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)CF
• 外观性状: 粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.549
• 储存条件: -15°C

Z-FA-FMK靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Compound was tested for inhibitory activity against cathepsin B 来源：ChEMBL 靶标：Cathepsin B External Id：CHEMBL657296

实验名称：Rate of cathepsin B inactivation in vitro in bovine spleen 来源：ChEMBL 靶标：Cathepsin B External Id：CHEMBL659002

实验名称：Compound was tested for inhibitory uM 来源：ChEMBL 靶标：Calpain-1 catalytic subunit External Id：CHEMBL658529

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Inhibition of SARS-CoV-2 main protease expressed in Escherichia coli using DABCYL-KTS... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL5147543

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Z-FA-FMK英文别名

• z-fa-fmk
• UNII:34O3P3306Z
• Nα-[(Benzyloxy)carbonyl]-N-(4-fluoro-3-oxo-2-butanyl)phenylalaninamide
• Carbamic acid, N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester
• Carbamic acid, N-[2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester
• Nα-[(Benzyloxy)carbonyl]-N-(4-fluoro-3-oxo-2-butanyl)-L-phenylalaninamide