197855-65-5

197855-65-5结构式

常用中文名：Z-FA-FMK
常用英文名：Z-FA-FMK
CAS号：197855-65-5
分子式：C₂₁H₂₃FN₂O₄
分子量：386.417
相关类别：生物化工抑制剂蛋白酶体(Proteases) Cysteine Protease 抑制剂
发布时间：2017-08-18 15:45:49
更新时间：2026-07-01 11:58:29
Z-FA-FMK ((1S)-Z-FA-FMK; Compound 6) 是一种广谱的卤代甲基酮抑制剂,可抑制冠状病毒 (SARS-CoV) 蛋白酶 3CL,Ki 为 25.7 μM。

中文名	Z-FA-FMK游离态
英文名	z-phe-dl-ala-fluoromethylketone
中文别名	半胱氨酸蛋白酶抑制剂 NALPHA-[(苄氧基)羰基]-N-(4-氟-3-氧代-2-丁烷基)苯丙氨酰胺
英文别名	Inhibitor of cysteine proteases Nalpha-[(Benzyloxy)carbonyl]-N-(4-Fluoro-3-Oxo-2-Butanyl)Phenylalaninamide z-fa-fmk z-fa-fmk Z-PHE-DL-ALA-FLUOROMETHYLKETONE Carbamic acid, N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester Benzyl ((2S)-1-((4-fluoro-3-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)cbamate Nα-[(Benzyloxy)carbonyl]-N-(4-fluoro-3-oxo-2-butanyl)-L-phenylalaninamide Nalpha-[(Benzyloxy)carbonyl]-N-(4-Fluoro-3-Oxo-2-Butanyl)Phenylalaninamide SS coronavirus,SS-CoV,RRMs,DNA fragmentation,DEVDase,Caspase,Cathsin,Inhibitor,externalization of phosphatidylserine,Apoptosis,inhibit,Z FA FMK,reovirus rlication,ZFAFMK Z-Phe-DL-Ala-FMK UNII:34O3P3306Z Nα-[(Benzyloxy)carbonyl]-N-(4-fluoro-3-oxo-2-butanyl)phenylalaninamide Carbamic acid, N-[2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester Cbamic acid,N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-,phenylmethyl ester Z-FA-FMK, 10 mM in DMSO

描述	Z-FA-FMK ((1S)-Z-FA-FMK; Compound 6) 是一种广谱的卤代甲基酮抑制剂,可抑制冠状病毒 (SARS-CoV) 蛋白酶 3CL,Ki 为 25.7 μM。
相关类别	研究领域 >> 感染信号通路 >> 抗感染 >> SARS冠状病毒
靶点	Ki: 25.7 μM (SARS Protease 3CLpro)[1]
参考文献	[1]. Usman Bacha, et al. Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro). Chem Biol Drug Des. 2008 Jul;72(1):34-49.