甲基赤芝萜酮

• 常用名: 甲基赤芝萜酮
• 英文名: Methyllucidone
• CAS号: 19956-54-8
• 分子量: 270.280
• 密度: 1.2±0.1 g/cm3
• 沸点: 514.0±50.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄O₄
• 熔点: N/A
• 闪点: 231.0±30.2 °C

甲基赤芝萜酮用途

甲基荧光素酮是一种神经保护剂和抗氧化剂,可从红果椴中分离出来。甲基卢西酮抑制ROS产生,并激活包括Nrf-2和PI3K在内的抗氧化信号通路[1]。

甲基赤芝萜酮名称

• 中文名: 甲基赤芝萜酮
• 英文名: 3,4,5-Trimethyl-2(1H)-pyridinone

甲基赤芝萜酮生物活性

• 描述: 甲基荧光素酮是一种神经保护剂和抗氧化剂,可从红果椴中分离出来。甲基卢西酮抑制ROS产生,并激活包括Nrf-2和PI3K在内的抗氧化信号通路[1]。
• 相关类别:
  信号通路 >> NF-κB信号通路 >> KEAP1-Nrf2
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Jee-Yun Park, et al. Methyl lucidone exhibits neuroprotective effects on glutamate-induced oxidative stress in HT-22 cells via Nrf-2/HO-1 signaling. Applied Biological Chemistry volume 62, Article number: 67 (2019).

甲基赤芝萜酮物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 514.0±50.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄O₄
• 分子量: 270.280
• 闪点: 231.0±30.2 °C
• 精确质量: 270.089203
• PSA: 52.60000
• LogP: 2.19
• InChIKey: FITVJPYUOAZKPN-PBMBQWDMSA-N
• SMILES: COC1=CC(=O)C(=C(C=Cc2ccccc2)OC)C1=O
• 外观性状: 粉末
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.581
• 储存条件: 2-8℃，干燥，密闭

甲基赤芝萜酮安全信息

• 危害码 (欧洲): Xi

甲基赤芝萜酮靶点实验

查看更多实验

实验名称：Inhibition of STAT5 phosphorylation in human DU145 cells after 24 hrs by Western blot... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 5A External Id：CHEMBL4220960

实验名称：Inhibition of STAT1 phosphorylation in human DU145 cells after 24 hrs by Western blot... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 1-alpha/beta External Id：CHEMBL4220959

实验名称：Modulation of MEG2 in human DU145 cells assessed as inhibition of STAT3 activation by... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 3 External Id：CHEMBL4220962

实验名称：Modulation of MEG2 in human DU145 cells assessed as inhibition of STAT3 activation by... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 3 External Id：CHEMBL4220961

实验名称：Modulation of MEG2 in human DU145 cells assessed as inhibition of STAT3 phosphorylati... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 3 External Id：CHEMBL4220956

实验名称：Effect on total STAT3 protein expression in human DU145 cells up to 20 uM after 24 hr... 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL4220958

实验名称：Modulation of MEG2 in human DU145 cells assessed as inhibition of STAT3 phosphorylati... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 3 External Id：CHEMBL4220957

实验名称：Antiproliferative activity against human DU145 cells by WST1 assay 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL4220967

实验名称：Antiproliferative activity against human PC3 cells by WST1 assay 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL4220970

实验名称：Antiproliferative activity against human LNCAP cells by WST1 assay 来源：ChEMBL 靶标：LNCaP External Id：CHEMBL4220969

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甲基赤芝萜酮英文别名

• (2Z)-4-Methoxy-2-[(2E)-1-methoxy-3-phenyl-2-propen-1-ylidene]-4-cyclopentene-1,3-dione