Chmfl-btk-01

• 常用名: Chmfl-btk-01
• 英文名: Chmfl-btk-01
• CAS号: 2095280-64-9
• 分子量: 647.76
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₈H₄₁N₅O₅
• 熔点: N/A
• 闪点: N/A

Chmfl-btk-01用途

CHMFL-BTK-01 (compound 9) 高度选择性的、不可逆的 BTK 抑制剂,IC50 值为 7 nM。CHMFL-BTK-01 (compound 9) 可有效抑制BTK Y223 的自磷酸化。

Chmfl-btk-01名称

• 英文名: CHMFL-BTK-01

Chmfl-btk-01生物活性

• 描述: CHMFL-BTK-01 (compound 9) 高度选择性的、不可逆的 BTK 抑制剂,IC50 值为 7 nM。CHMFL-BTK-01 (compound 9) 可有效抑制BTK Y223 的自磷酸化。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> BTK
• 靶点实验:

  IC50: 7 nM (BTK)[1].

• 参考文献:

  [1]. Liang Q, et al. Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor. Eur J Med Chem. 2017 May 5;131:107-125.

Chmfl-btk-01物理化学性质

• 分子式: C₃₈H₄₁N₅O₅
• 分子量: 647.76
• InChIKey: UBXBHXGYYBYXOB-UHFFFAOYSA-N
• SMILES: C=CC(=O)Nc1cc(Nc2cc(-c3cccc(NC(=O)c4ccc(C(C)(C)C)cc4)c3C)cn(C)c2=O)ccc1C(=O)N1CCOCC1

Chmfl-btk-01靶点实验

查看更多实验

实验名称：Inhibition of full length recombinant human N-terminal His tagged BKT expressed in ba... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL4024931

实验名称：Effect on BTK transphosphorylation at PLCgamma2 Y759 in human U2932 cells up to 1 uM ... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL4024954

实验名称：Inhibition of BTK transphosphorylation at PLCgamma2 Y1217 in human U2932 cells up to ... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL4024955

实验名称：Effect on BTK transphosphorylation at Y551 in human U2932 cells up to 1 uM measured a... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL4024952

实验名称：Effect on BTK transphosphorylation at PLCgamma1 Y783 in human U2932 cells up to 1 uM ... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL4024953

实验名称：Cytotoxicity against PBMC (unknwon origin) 来源：ChEMBL 靶标：PBMC External Id：CHEMBL4024950

实验名称：Cell cycle arrest in human Pfeiffer cells assessed as increase in accumulation at G0/... 来源：ChEMBL 靶标：Pfeiffer External Id：CHEMBL4024962

实验名称：Induction of apoptosis in human U2932 cells assessed as induction of PARP cleavage af... 来源：ChEMBL 靶标：U2932 External Id：CHEMBL4024963

实验名称：Inhibition of BTK transphosphorylation at PLCgamma2 Y1217 in human Pfeiffer cells up ... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL4024960

实验名称：Cell cycle arrest in human U2932 cells assessed as increase in accumulation at G0/G1 ... 来源：ChEMBL 靶标：U2932 External Id：CHEMBL4024961

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