IDO1-IN-22

• 常用名: IDO1-IN-22
• 英文名: IDO1-IN-22
• CAS号: 2126853-16-3
• 分子量: 387.16
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₁₂BrFN₆O₃
• 熔点: N/A
• 闪点: N/A

IDO1-IN-22用途

IDO1-IN-22(化合物3)是IDO1抑制剂(生物化学hIDO1 IC50:67.4nM,HeLa hIDO1IC50:17.6nM)。IDO1-IN-22在LLC异种移植物模型中具有优异的抗肿瘤功效,以及理想的药代动力学(PK)特征[1]。

IDO1-IN-22名称

• 英文名: IDO1-IN-22

IDO1-IN-22生物活性

• 描述: IDO1-IN-22(化合物3)是IDO1抑制剂(生物化学hIDO1 IC50:67.4nM,HeLa hIDO1IC50:17.6nM)。IDO1-IN-22在LLC异种移植物模型中具有优异的抗肿瘤功效,以及理想的药代动力学(PK)特征[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 吲哚胺2,3-二氧化酶(IDO)
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Ye K, et al. Design, synthesis, biological evaluation of urea substituted 1,2,5-oxadiazole-3-carboximidamides as novel indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors. Eur J Med Chem. 2023 Mar 15;250:115217.

IDO1-IN-22物理化学性质

• 分子式: C₁₂H₁₂BrFN₆O₃
• 分子量: 387.16

IDO1-IN-22靶点实验

查看更多实验

实验名称：Efflux ratio of apparent permeability from apical to basolateral side over basolatera... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5388212

实验名称：Apparent permeability of the compound across basolateral to apical side in dog MDCKII... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5388211

实验名称：Apparent permeability of the compound across apical to basolateral side in dog MDCK-I... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5388210

实验名称：Inhibition of human recombinant TDO assessed as reduction in N-formylkynurenine forma... 来源：ChEMBL 靶标：Tryptophan 2,3-dioxygenase External Id：CHEMBL5388205

实验名称：Inhibition of human recombinant IDO2 assessed as reduction in N-formylkynurenine form... 来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 2 External Id：CHEMBL5388204

实验名称：Inhibition of IDO1 in IFN-gamma-induced human HeLa cells assessed as reduction in N-f... 来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1 External Id：CHEMBL5388203

实验名称：Inhibition of human recombinant IDO1 assessed as reduction in N-formylkynurenine form... 来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1 External Id：CHEMBL5388202

实验名称：Toxicity in C57BL/6 mouse implanted with mouse LLC cells assessed as change in body w... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5388201

实验名称：Toxicity in C57BL/6 mouse implanted with mouse LLC cells assessed as kidney function ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5388237

实验名称：Toxicity in C57BL/6 mouse implanted with mouse LLC cells assessed as liver function b... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5388236

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