氟米松结构式
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常用名 | 氟米松 | 英文名 | Flumethasone |
---|---|---|---|---|
CAS号 | 2135-17-3 | 分子量 | 410.452 | |
密度 | 1.4±0.1 g/cm3 | 沸点 | 569.8±50.0 °C at 760 mmHg | |
分子式 | C22H28F2O5 | 熔点 | 237-240ºC | |
MSDS | 中文版 美版 | 闪点 | 298.4±30.1 °C | |
符号 |
GHS08 |
信号词 | Warning |
氟米松用途Flumethasone是一种皮质类固醇,是一种局部用药,与Clioquinol联用治疗外耳炎和耳真菌病, Flumethasone作用于动物模型时, 抗炎活性比Cortisone高420倍。 |
中文名 | 氟米松 |
---|---|
英文名 | flumethasone |
中文别名 | 6Α-氟地塞米松 | 氟甲松 |
英文别名 | 更多 |
密度 | 1.4±0.1 g/cm3 |
---|---|
沸点 | 569.8±50.0 °C at 760 mmHg |
熔点 | 237-240ºC |
分子式 | C22H28F2O5 |
分子量 | 410.452 |
闪点 | 298.4±30.1 °C |
精确质量 | 410.190491 |
PSA | 94.83000 |
LogP | 1.61 |
蒸汽压 | 0.0±3.6 mmHg at 25°C |
折射率 | 1.579 |
储存条件 | 2-8°C |
计算化学 | 1.疏水参数计算参考值(XlogP):无 2.氢键供体数量:3 3.氢键受体数量:7 4.可旋转化学键数量:2 5.互变异构体数量:3 6.拓扑分子极性表面积:94.8 7.重原子数量:29 8.表面电荷:0 9.复杂度:839 10.同位素原子数量:0 11.确定原子立构中心数量:9 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
符号 |
GHS08 |
---|---|
信号词 | Warning |
危害声明 | H351 |
警示性声明 | P281 |
个人防护装备 | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
危害码 (欧洲) | Xn:Harmful |
风险声明 (欧洲) | R40 |
安全声明 (欧洲) | S22-S36 |
危险品运输编码 | NONH for all modes of transport |
WGK德国 | 3 |
RTECS号 | TU3832000 |
海关编码 | 2937229000 |
~% 氟米松 2135-17-3 |
文献:WO2012/11106 A1, ; Page/Page column 20 ; |
~% 氟米松 2135-17-3 |
文献:Farmaco, , vol. 51, # 12 p. 809 - 810 |
~% 氟米松 2135-17-3 |
文献:WO2012/11106 A1, ; |
海关编码 | 2937229000 |
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Tympanoplasty graft preparation using ear drops containing polyethylene glycol, flumethasone and clioquinol.
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Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl- |
6a-Fluorodexamethasone |
Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)- |
(6α,11β,16α)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione |
6α-Fluorodexamethasone |
6α,9α-Difluoro-16α-methylprednisolone |
Aniprime |
Flumethasone |
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluor-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-on |
Fluvet |
EINECS 218-370-9 |
flumetasone |
6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione |
Flucorticin |
Anaprime |
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one |
MFCD00056464 |
Flumethason |
Cortexilar |
6a,9a-Difluoro-16a-methylprednisolone |
Methagon |
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |