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氟米松

更新时间:2024-01-02 18:54:50

氟米松结构式
氟米松结构式
品牌特惠专场
常用名 氟米松 英文名 Flumethasone
CAS号 2135-17-3 分子量 410.452
密度 1.4±0.1 g/cm3 沸点 569.8±50.0 °C at 760 mmHg
分子式 C22H28F2O5 熔点 237-240ºC
MSDS 中文版 美版 闪点 298.4±30.1 °C
符号 GHS08
GHS08
信号词 Warning

 氟米松用途


Flumethasone是一种皮质类固醇,是一种局部用药,与Clioquinol联用治疗外耳炎和耳真菌病, Flumethasone作用于动物模型时, 抗炎活性比Cortisone高420倍。

 氟米松名称

中文名 氟米松
英文名 flumethasone
中文别名 6Α-氟地塞米松 | 氟甲松
英文别名 更多

 氟米松生物活性

描述 Flumethasone是一种皮质类固醇,是一种局部用药,与Clioquinol联用治疗外耳炎和耳真菌病, Flumethasone作用于动物模型时, 抗炎活性比Cortisone高420倍。
相关类别

 氟米松物理化学性质

密度 1.4±0.1 g/cm3
沸点 569.8±50.0 °C at 760 mmHg
熔点 237-240ºC
分子式 C22H28F2O5
分子量 410.452
闪点 298.4±30.1 °C
精确质量 410.190491
PSA 94.83000
LogP 1.61
蒸汽压 0.0±3.6 mmHg at 25°C
折射率 1.579
储存条件 2-8°C
计算化学

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:3

3.氢键受体数量:7

4.可旋转化学键数量:2

5.互变异构体数量:3

6.拓扑分子极性表面积:94.8

7.重原子数量:29

8.表面电荷:0

9.复杂度:839

10.同位素原子数量:0

11.确定原子立构中心数量:9

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

 氟米松毒性和生态

 氟米松安全信息

符号 GHS08
GHS08
信号词 Warning
危害声明 H351
警示性声明 P281
个人防护装备 Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲) Xn:Harmful
风险声明 (欧洲) R40
安全声明 (欧洲) S22-S36
危险品运输编码 NONH for all modes of transport
WGK德国 3
RTECS号 TU3832000
海关编码 2937229000

 氟米松合成线路

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氟米松结构式

氟米松

2135-17-3

文献:WO2012/11106 A1, ; Page/Page column 20 ;

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氟米松结构式

氟米松

2135-17-3

文献:Farmaco, , vol. 51, # 12 p. 809 - 810

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氟米松结构式

氟米松

2135-17-3

文献:WO2012/11106 A1, ;

 氟米松海关

海关编码 2937229000

 氟米松文献29

更多文献
Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea.

Food. Addit. Contam. Part. B. Surveill. 8 , 106-12, (2015)

The Korean National Residue Programme comprises three different approaches for evaluating domestic and imported foods of animal origin: monitoring, surveillance/enforcement and an exploratory test pro...

Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation.

Int. J. Pharm. 370(1-2) , 181-6, (2009)

Charged drug delivery systems are interesting candidates for the delivery of drugs through skin. In the present study, it was possible to create negatively and positively charged oil/water nanoemulsio...

Tympanoplasty graft preparation using ear drops containing polyethylene glycol, flumethasone and clioquinol.

J. Laryngol. Otol. 125(8) , 853-5, (2011)

The aim of tympanoplasty graft preparation is to stiffen the fascia or perichondrium and thereby to optimise ease of manipulation. We report 39 cases utilising a novel technique in which the graft is ...

 氟米松英文别名

Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl-
6a-Fluorodexamethasone
Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-
(6α,11β,16α)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
6α-Fluorodexamethasone
6α,9α-Difluoro-16α-methylprednisolone
Aniprime
Flumethasone
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluor-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-on
Fluvet
EINECS 218-370-9
flumetasone
6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
Flucorticin
Anaprime
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
MFCD00056464
Flumethason
Cortexilar
6a,9a-Difluoro-16a-methylprednisolone
Methagon
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
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