2135-17-3

• 常用中文名：氟米松
• 常用英文名：Flumethasone
• CAS号：2135-17-3
• 分子式：C₂₂H₂₈F₂O₅
• 分子量：410.452
• 相关类别： 生物化工 抑制剂 内分泌及激素(Endocrinology & Hormones) Glucocorticoid Receptor 激动剂
• 发布时间：2018-06-14 18:00:08
• 更新时间：2024-01-02 18:54:50
• Flumethasone是一种皮质类固醇，是一种局部用药，与Clioquinol联用治疗外耳炎和耳真菌病, Flumethasone作用于动物模型时, 抗炎活性比Cortisone高420倍。

名称

• 中文名: 氟米松
• 英文名: flumethasone
• 中文别名: 6Α-氟地塞米松; 氟甲松
• 英文别名: Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl-; 6a-Fluorodexamethasone; Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-; (6α,11β,16α)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 6α-Fluorodexamethasone; 6α,9α-Difluoro-16α-methylprednisolone; Aniprime; Flumethasone; (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluor-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-on; Fluvet; EINECS 218-370-9; flumetasone; 6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; Flucorticin; Anaprime; (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; MFCD00056464; Flumethason; Cortexilar; 6a,9a-Difluoro-16a-methylprednisolone; Methagon; (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 569.8±50.0 °C at 760 mmHg
• 熔点: 237-240ºC
• 分子式: C₂₂H₂₈F₂O₅
• 分子量: 410.452
• 闪点: 298.4±30.1 °C
• 精确质量: 410.190491
• PSA: 94.83000
• LogP: 1.61
• 蒸汽压: 0.0±3.6 mmHg at 25°C
• 折射率: 1.579
• 储存条件: 2-8°C
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:3

  3.氢键受体数量:7

  4.可旋转化学键数量:2

  5.互变异构体数量:3

  6.拓扑分子极性表面积:94.8

  7.重原子数量:29

  8.表面电荷:0

  9.复杂度:839

  10.同位素原子数量:0

  11.确定原子立构中心数量:9

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: Flumethasone是一种皮质类固醇,是一种局部用药,与Clioquinol联用治疗外耳炎和耳真菌病, Flumethasone作用于动物模型时, 抗炎活性比Cortisone高420倍。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU3832000 CHEMICAL NAME : Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alpha- methyl- CAS REGISTRY NUMBER : 2135-17-3 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C22-H28-F2-O5 MOLECULAR WEIGHT : 410.50 WISWESSER LINE NOTATION : L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1 FQ G1 LF HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 20 ug/kg SEX/DURATION : female 38 week(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 28,407,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 30 ug/kg SEX/DURATION : female 31 week(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 160,867,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 20 ug/kg SEX/DURATION : female 40 week(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition REFERENCE : THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 20,267,1983

安全

• 符号: GHS08
• 信号词: Warning
• 危害声明: H351
• 警示性声明: P281
• 个人防护装备: Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): Xn:Harmful
• 风险声明 (欧洲): R40
• 安全声明 (欧洲): S22-S36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: TU3832000
• 海关编码: 2937229000

合成路线

23961-95-7 ~% 2135-17-3

文献：WO2012/11106 A1, ; Page/Page column 20 ;

2002-29-1 ~% 2135-17-3

文献：Farmaco, , vol. 51, # 12 p. 809 - 810

4571-51-1 ~% 2135-17-3

文献：WO2012/11106 A1, ;

上下游产品

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23961-95-7 2002-29-1 4571-51-1
下游产品  2
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海关

海关编码	2937229000