6-Hydroxy-DOPA

更新时间：2024-01-12 17:50:15

6-Hydroxy-DOPA结构式	常用名	6-Hydroxy-DOPA	英文名	6-Hydroxy-DL-DOPA
	CAS号	21373-30-8	分子量	213.18700
	密度	1.606g/cm3	沸点	515.2ºC at 760mmHg
	分子式	C₉H₁₁NO₅	熔点	N/A
	MSDS	美版	闪点	265.4ºC

6-Hydroxy-DOPA用途

6-羟基多巴是RAD52单链DNA结合域选择性和有效的变构抑制剂。6-羟基多巴可用于癌症研究[1]。

中文名	6-羟基-DL-DOPA
英文名	6-hydroxydopa
英文别名	更多

描述	6-羟基多巴是RAD52单链DNA结合域选择性和有效的变构抑制剂。6-羟基多巴可用于癌症研究[1]。
相关类别	研究领域 >> 癌症信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
靶点	RAD52[1]
体外研究	6-羟基多巴(0~20μM；U20S细胞)选择性抑制RAD52介导的重组。6-羟基多巴(0~10μM；HEK293T细胞)以剂量依赖性方式减少eGFP-RAD52病灶的数量。6-羟基多巴(5～75μM；HCC1937细胞)选择性降低BRCA1缺陷型三阴性乳腺癌细胞系HCC1937的生存能力[1]。
参考文献	[1]. Chandramouly G, et al. Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem Biol. 2015;22(11):1491-1504.

密度	1.606g/cm3
沸点	515.2ºC at 760mmHg
分子式	C₉H₁₁NO₅
分子量	213.18700
闪点	265.4ºC
精确质量	213.06400
PSA	124.01000
LogP	0.45810
储存条件	2-8°C，密封，干燥

6-Hydroxy-DOPAMSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
安全声明 (欧洲)	22-24/25
危险品运输编码	NONH for all modes of transport

The free radical site in pea seedling copper amine oxidase probed by resonance Raman spectroscopy and generated by photolysis of caged substrate.

FEBS Lett. 380(1-2) , 183-7, (1996)

Resonance Raman spectra were obtained of the free radical site in substrate reduced anaerobic samples of pea seedling copper amine oxidase (PSAO). The spectra differ significantly from those reported ...

Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6-hydroxydopamine rat model of Parkinson's disease.

Synapse 61 , 606-614, (2007)

Evidence obtained in rodent and primate models of Parkinson's disease (PD) and preliminary clinical trials, indicates that adenosine A(2A) receptor antagonists might represent a promising nondopaminer...

Up-regulation in expression of vesicular glutamate transporter 3 in substantia nigra but not in striatum of 6-hydroxydopamine-lesioned rats.

Neurosignals 15(5) , 238-48, (2006)

Overactivity of the glutamatergic system is suggested to be closely related to the onset and pathogenesis of Parkinson's disease. Vesicular glutamate transporters (VGLUT1, T2 and T3) are a group of gl...

2,5-Dihydroxytyrosine