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苯并二氧六环-6-(1-哌啶基)甲酰胺

苯并二氧六环-6-(1-哌啶基)甲酰胺用途

CX546是AMPAR受体选择性激动剂。

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苯并二氧六环-6-(1-哌啶基)甲酰胺名称

[ CAS 号 ]:
215923-54-9

[ 中文名 ]:
2-溴-1-(2,6-二氯苯基)乙酮

[ 英文名 ]:
CX546

[中文别名 ]:

[英文别名 ]:

CX 546
Lopac-C-271
BDP 17
GR 87
CX546

苯并二氧六环-6-(1-哌啶基)甲酰胺生物活性

[ 描述 ]:

CX546是AMPAR受体选择性激动剂。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

[参考文献]

[1]. Lauterborn JC, et al. Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci. 2000 Jan 1;20(1):8-21.

[2]. Nagarajan N, et al. Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546. Neuropharmacology. 2001 Nov;41(6):650-63.

[3]. Arai AC, et al. Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. J Pharmacol Exp Ther. 2002 Dec;303(3):1075-85.

[4]. Lipina T, et al. The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice. Neuropsychopharmacology. 2007 Apr;32(4):745-56.

[相关活性小分子]

苯并二氧六环-6-(1-哌啶基)甲酰胺物理化学性质

[ 密度 ]:
1.215g/cm3

[ 沸点 ]:
422.8ºC at 760 mmHg

[ 分子式 ]:
C₁₄H₁₇NO₃

[ 分子量 ]:
247.29000

[ 闪点 ]:
209.5ºC

[ 精确质量 ]:
247.12100

[ PSA ]:
38.77000

[ LogP ]:
2.02180

[ 蒸汽压 ]:
2.34E-07mmHg at 25°C

[ 折射率 ]:
1.573

[ 储存条件 ]:
2-8℃

苯并二氧六环-6-(1-哌啶基)甲酰胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

苯并二氧六环-6-(1-哌啶基)甲酰胺海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

苯并二氧六环-6-(1-哌啶基)甲酰胺文献

Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex.

Eur. Psychiatry 29(7) , 419-23, (2014)

Ketamine exerts fast acting, robust, and lasting antidepressant effects in a sub-anesthetic dose, however, the underlying mechanisms are still not fully elucidated. Recent studies have suggested that ...

Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action.

J. Pharmacol. Exp. Ther. 303 , 1075-1085, (2002)

CX516 (BDP-12) and CX546, two first-generation benzamide-type AMPA receptor modulators, were compared with regard to their influence on AMPA receptor-mediated currents, autaptic responses in cultured ...

Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM.

Proc. Natl. Acad. Sci. U. S. A. 95 , 2597-2602, (1998)

To study regulation in vivo of the promoter for the neural cell adhesion molecule, N-CAM, we have used homologous recombination to insert the bacterial lacZ gene between the transcription and translat...

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