ACT-1004-1239

• 常用名: ACT-1004-1239
• 英文名: ACT-1004-1239
• CAS号: 2178049-58-4
• 分子量: 522.55
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₈F₂N₆O₃
• 熔点: N/A
• 闪点: N/A

ACT-1004-1239用途

ACT-1004-1239是一种有效、选择性、口服的CXCR7拮抗剂,IC50值为3.2 nM。

ACT-1004-1239名称

• 英文名: ACT-1004-1239

ACT-1004-1239生物活性

• 描述: ACT-1004-1239是一种有效、选择性、口服的CXCR7拮抗剂,IC50值为3.2 nM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> CXCR
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> CXCR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Richard-Bildstein S, et al. Discovery of the Potent, Selective, Orally Available CXCR7 Antagonist ACT-1004-1239. J Med Chem. 2020 Dec 24;63(24):15864-15882.

ACT-1004-1239物理化学性质

• 分子式: C₂₇H₂₈F₂N₆O₃
• 分子量: 522.55

ACT-1004-1239靶点实验

查看更多实验

实验名称：Inhibition of human ERG expressed in CHO cells at -40 mV holding potential by Q-patch... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4706357

实验名称：Antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expres... 来源：ChEMBL 靶标：Atypical chemokine receptor 3 External Id：CHEMBL4706356

实验名称：Plasma concentration in DBA/1 mouse plasma at 100 mg/kg, po administered as single do... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4706409

实验名称：Plasma concentration in DBA/1 mouse plasma at 30 mg/kg, po administered as single dos... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4706408

实验名称：In-vivo antagonist activity at CXCR7 in DBA/1 mouse assessed as increase in plasma CX... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4706399

实验名称：In-vivo antagonist activity at CXCR7 in DBA/1 mouse assessed as increase in plasma CX... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4706398

实验名称：In-vivo antagonist activity at CXCR7 in DBA/1 mouse assessed as increase in plasma CX... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4706401

实验名称：In-vivo antagonist activity at CXCR7 in DBA/1 mouse assessed as increase in plasma CX... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4706400

实验名称：In-vivo antagonist activity at CXCR7 in DBA/1 mouse assessed as increase in plasma CX... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4706403

实验名称：In-vivo antagonist activity at CXCR7 in DBA/1 mouse assessed as increase in plasma CX... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4706402

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